Orally Administered Sulfonylurea Hypoglycemic Agents

TABLE 1 Comparison of Orally Administered Characteristics Tolbutamide Sulfonylurea Hypoglycemic Agents Acetohexamide Tolazamide Chlorpropamide Glipizide Glyburide [Pg.38]

Fecal excretion (% of dose) Negligible Negligible Negligible Negligible 12 50 [Pg.38]

The major indication for carbonic anhydrase inhibitors is open-angle glaucoma. Carbonic anhydrase inhibitors also may be employed for secondary glaucoma and preop-eratively in acute angle-closure glaucoma to lower intraocular pressure before surgery. Acetazolamide also is used for the treatment of epilepsy. The rapid development of tolerance, however, may limit the usefulness of carbonic anhydrase inhibitors for epilepsy. [Pg.38]

Acetic acid (2 drops in each ear b.i.d.) is an antibacterial and antifungal agent, which is indicated in the treatment of external ear canal infection. [Pg.38]

Acetohexamide is a blood-glucose-lowering drug of the sulfonylurea class. The first-generation oral hypoglycemic agents include tolbutamide (Orinase), acetohexamide (Dymelor), tolazamide (Tolinase), and chlorpropamide [Pg.38]

Big Chemical Encyclopedia