Biguanides, Oral hypoglycemic

NONCYCLIC ALIPHATICS Many of the biguanides have oral hypoglycemic activity, and metformin (87) is such an antidiabetic agent. Cyanamide has a highly reactive nitrile function because of the electropositive NH2 group... 

Oral hypoglycemics Sulfonylureas Biguanides Th iaz o 1 idinediones Acarbose... 

Biguanides have been used for a variety of purposes in medical practice but their clinical importance is undoubtedly dominated by their valuable antimalarial and oral hypoglycemic properties. These functions have been closely studied in an effort to gain an imderstanding of the mode of... 

Four groups of drugs have been shown to affect the absorption of vitamin B12. These include the oral hypoglycemic biguanides, colchicine, ethanol, and aminosalicylic acid. 

Simple Electron Capture Gas Chromatographic Method for the Determination of Oral Hypoglycemic Biguanides in Biological Fluids Anal. Chem. 47(3) 545-548 (1975) CA 83 129m... 

Phenformin (27) used clinically as an oral hypoglycemic agent, in common with the biguanides, degrades on volatilization. 

Yet another example of a so-called pharmacophoric group is the biguanide functionality, a grouping associated with oral antidiabetic activity (see the section on sulfonylureas for a fuller discussion of this activity). Condensation of 2-phenethylamine with dicyanamide affords directly the orally active hypoglycemic agent phenformin (88). ... 

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