Hypoallergenicity

HELM R M, BURKS A w (1996) Hypoallergenicity of rice protein. Cereal Foods World, 4(11) 839 3. 

Negative claims such as nonirritating or hypoallergenic also must be proved and it is generally the responsibility of the product safety professional to provide proof for them. There are special tests for such claims. 

Sulfosuccinates, as presented with their general structural formula in Fig. 2.11.33, are applied as surfactants for personal hygiene because of their hypoallergenic features. The sodium salt of the sulfosuccinate blend with the formula ROOC-CH-(SC>3 )-CH2-COOR Na+ (R = CsH-iy) was examined by APCI-FIA-MS in the positive and negative modes. The addition of an excess of ammonium acetate under FIA-APCI-MS(+) conditions resulted in [M — NH4]+ ions with mlz 440 while [M — H] ions with mlz 421, however, were observed in the negative APCI-FIA-MS mode (Fig. 2.11.34(a)). Only one type of ion could be observed in this industrial blend by FIA-MS. This purity could also be confirmed by APCI-LC-MS(-), as shown in the total ion current trace (cf. Fig. 2.11.34(b)), which is presented in combination with the averaged mass spectrum under the signal in the inset of Fig. 2.11.34(b) [22],... 

Nakamura, T., et al. (1993). Enzymatic production of hypoallergenic peptides from... 

Watanabe, M. (1994). Controlled enzymatic treatment of wheat proteins for production of hypoallergenic flour, Biosci. Biotech. Biochem., 58, 388-390. 

In a mouse model of aerosol sensitization to birch pollen we previously demonstrated that intranasal as well as oral administration of the major birch pollen allergen Bet v 1 prevented allergic sensitization, airway inflammation and airway hyperresponsiveness [28], Similar effects were achieved using hypoallergenic derivates of Bet v 1, containing the immunodominant T cell peptides but not the anaphylactogenic B cell epitopes, for intranasal tolerance induction [60],... 

It is of particular clinical relevance to test the effects of mucosal allergen application in already sensitized organisms. The obvious advantage of the use of so-called hypoallergenic molecules lies in their risk-free application. Thus, the practical consequences from such experimental studies could include the development of low-risk mucosal vaccines based on the induction of tolerance - with or without the use of certain mucosal antigen delivery systems. 

Wiedermann U, Herz U, Baier K, Vrtala S, Neuhaus-Steinmetz U, Bohle B, Dekan G, Renz H, Ebner C, Valenta R, Kraft D Intranasal treatment with a recombinant hypoallergenic derivative of the major birch pollen allergen Bet v 1 prevents allergic sensitization and airway inflammation in mice. Int Arch Allergy Immunol 2001 126 68-77. 

Aloe gel is also present in many cosmetics for its emollient properties and antiaging effects on the skin. Although aloe is considered hypoallergenic even in large doses, allergic contact dermatitis due to the topical application of gel preparations has been described. 

Uses As a hypoallergenic developing agent (this means it is unlikely to cause dermatitis) that can be substituted for metol. Sufferers of metol poisoning can often use Phenidone-based developers without ill effects. 

Ferreira, F., C. Ebner, B. Kramer, G. Casari, P. Briza, A. J. Kungl, R. Grimm, B. Jahn-Schmid, H. Breiteneder, D. Kraft, M. Breitenbach, H. J. Rheinberger, and O. Scheiner. 1998. Modulation of IgE reactivity of allergens by site-directed mutagenesis Potential use of hypoallergenic variants for immunotherapy. FASEB J 12 (2) 231-242. 

Swoboda, I., A. Bugajska-Schretter, B. Linhart, P. Verdino, W. Keller, U. Schulmeister, W. R. Sperr, P. Valent, G. Peltre, S. Quirce, N. Douladiris, N. G. Papadopoulos, R. Valenta, and S. Spitzauer. 2007. A recombinant hypoallergenic parvalbumin mutant for immunotherapy of IgE-mediated fish allergy../ Immunol 178 (10) 6290-6296. 

A synthetic amino acid mixture is the only completely hypoallergenic product, but it can be used only parenterally. Consumption of amino acids cannot stimulate oral tolerance in an organism. 

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