Fish allergy

Parvalbumin was found to be a major fish allergen in approximately 70% of fish allergies, mediated by parvalbumin IgE antibodies, leading to respiratory and gastrointestinal symptoms. Parvalbumin also became of interest because of its potential use in gene therapy to correct cardiomyopathy. 

Pascual, C., Esteban, M. and Crespo, F. (1992). Fish allergy Evaluation of the importance of cross-reactivity, J. Pediatr., 121, 29-34. 

Taylor, S. L., Kabourek, J. L., and Hefle, S. L. (2004). Fish allergy Fish and products thereof. J. Food Sci. 69, R175-R180. 

About 28% of patients develop IgG or IgE antibodies after a single exposure to protamine, but fortunately few develop a catastrophic allergic reaction on subsequent exposure to the drug. Nonetheless, prior exposure does increase the risk for an anaphylactic reaction. Other risk factors are fish allergy and patients with diabetes mellitus treated with neutral protamine Flagedorn (NPFI) insulin. After vasectomy, 22%... 

Sakaguchi, M., Toda, M., Ebihara, T., Irie, S., Hori, H., Imai, A., Yanagida, M., Miyazawa, H., Ohsuna, H., Ikezawa, Z., and Inoue, S. (2000). IgE antibody to fish gelatin (type I collagen) in patients with fish allergy. ]. Allergy Clin. Immunol. 106, 579-584. 

Swoboda, I., A. Bugajska-Schretter, B. Linhart, P. Verdino, W. Keller, U. Schulmeister, W. R. Sperr, P. Valent, G. Peltre, S. Quirce, N. Douladiris, N. G. Papadopoulos, R. Valenta, and S. Spitzauer. 2007. A recombinant hypoallergenic parvalbumin mutant for immunotherapy of IgE-mediated fish allergy../ Immunol 178 (10) 6290-6296. 

Hansen, T. K., Skov, S. P, Poulsen, L. K., and Bindslev-Jensen, C. 1994. Allergenic activity of processed fish. Allergy Clin Immunol News Suppl 2 445. 

Helbling, A., Haydel, R., McCants, M. L., Musmand, J. J., El-Dahr, J., and Lehrer, S. B. 1999. Fish allergy Is cross-reactivity among fish species relevant Double-blind placebo-controlled food challenge studies of fish allergic adults. Ann Allergy Asthma Immunol 83 517-523. 

Fish allergy with increased IgE total concentrations and specific IgE antibodies against various fish products have been reported in two children with Uver transplants (88). Even though both patients had a personal or familial history of aUery, this again suggested a possible relation between tacrolimus and food allergy. 

Between 2.3 and 39% of children and adults allergic to food have been diagnosed with fish allergy, depending on the different study cohorts (Aas, 1966 Dannaeus and Inganas, 1981 Bock and Atkins, 1990 Crespo et al., 1992 De Martino et al., 1993 Andre et al., 1994 Moneret-Vautrin and Kanny, 1995 Novembre et al., 1998 Ranee et al., 1999 Lopata and Jeebhay, 2001 Ranee and Dutau, 2002). 

Fish parvalbumins are considered to be the major and sole allergens for 95% of patients suffering from IgE-mediated fish allergy (Swoboda et al., 2002). The protein contains at least five IgE binding linear and conformational epitopes (Elsayed and Apold, 1983 Untersmayr etal., 2006). They may not be of equal importance and could provoke reactions of varying severity in allergic patients. 

Andre F, Cavagna S, Andre C (2003). Gelatin prepared from tuna skin a risk factor for fish allergy or sensitization Int. Arch. Allergy Immunol., 130 17-24. 

Elsayed S (2002). Fish allergy and the codfish allergen model. In Brostoff J, CaUacombe SJ, (eds. ), Food Allergy and Intolerance, 2nd ed. Harcourt, London, pp. 425 33. 

Helbing A, Lopez M, Lehrer SB (1992). Fish allergy Is it a real problem with surimi-based products Int. Arch. Allergy Immunol, 99 452-455. 

Sakaguchi M (2000). IgE antibody to fish gelatin (type I collagen) in patients with fish allergy. J. Allergy Clin. Immunol, 106 579-584. 

Swoboda I, Bugajska-Schretter A, Verdino P, et al. (2002). Recombinant carp parvalbumin, the major cross-reactive fish allergen a tool for diagnosis and therapy of fish allergy. J. Immunol, 168 4576 584. 

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