Hypertonia

Moderate Abrupt weakness, visual disturbance, excess of salivation, sweating, vomiting, diarrhea, bradycardia, hypertonia, tremors of hands and head, disturbed gait, miosis, chest pain, cyanosis of the mucous membranes Convalescence in 1-2 weeks... 

CDC Case Definition Acute onset of hypertonia and/or painful muscular contractions (usually of the muscles of the jaw and neck) and generalized muscle spasms without other apparent medical cause. 

Other causes of PKU secondary to defective tetrahydrobiopterin synthesis include GTP cyclohydrolase deficiency and 6-pyravoyltetrahydrobiopterin synthase deficiency. Patients with either defect have psychomotor retardation, truncal hypotonia with limb hypertonia, seizures and a tendency to hyperthermia. The intravenous administration of BH4 may lower blood phenylalanine levels but this cofactor may not readily cross the blood-brain barrier. Treatment with synthetic pterin analogs or supplementation with tryptophan and carbidopa may prove more efficacious, particularly if treatment is started early in life. 

A 9-week-old boy, healthy at birth, begins to develop symptoms of ketoacidosis, vomiting, lethargy, seizures and hypertonia. Urine has characteristic odor of maple syrup. 

Cocaine readily penetrates mucous membranes and is an effective topical local anaesthetic that demonstrates intensive vasoconstrictor action. It has stimulant effects on the central nervous system and is a drug of addiction. It causes agitation, dilated pupils, tachycardia, hypertension, hallucinations, hyperthermia, hypertonia, hyperreflexia and cardiac effects. 

Therapeutic indications for benzodiazepines include anxiety states associated with neurotic, phobic, and depressive disorders, or myocardial infarction (decrease in cardiac stimulation due to anxiety) insomnia preanesthetic (preoperative) medication epileptic seizures and hypertonia of skeletal musculature (spasticity, rigidity). 

Discontinuing therapy If therapy needs to be discontinued, especially in patients who have been receiving high doses for long periods, the dose should be decreased slowly to minimize the risk of withdrawal and rebound hypertension, tachycardia, and hypertonia. 

In general, adverse events occur within the first week following injection of botulinum toxin type A and, while generally transient, may have a duration of several months. CD. Adverse reactions in at least 3% of patients include dysphagia, upper respiratory infection, neck pain, headache, dyspnea, increased cough, flu syndrome, back pain, rhinitis, dizziness, hypertonia, injection site soreness, asthenia, oral dryness, speech disorder, fever, nausea, and drowsiness. 

Adverse reactions may include abdominal pain/cramps/discomfort colitis exacerbation constipation diarrhea dyspepsia eructation flatulence/gas nausea vomiting asthenia chills dizziness fever headache malaise/fatigue/weakness sweating pharyngitis rhinitis pruritus rash/spots arthralgia back pain hypertonia myalgia chest pain dysmenorrhea edema flu syndrome pain. 

Chiidren with Krabbe disease exhibit irritabiiity, fever, seizures, iimb stiffness, deiayed mentai or motor deveiopment, vomiting, feeding difficuities, hypertonia, spasticity, deafness, and biindness. 

It is noteworthy that this formulation is different from fluorosilicones. Fluorosili-cones are fluorine-containing silicone oils with a 1.35 g/cm density. Their poor tolerance in animals and men was demonstrated by experimental studies [45,46] ocular hypertonia, keratopathy, early emulsification and severe inflammatory reactions. They cannot therefore be used as a heavy internal tamponade product. 

In the clinical study, perioperative complications were highlighted by two cases of early and unexplained emulsification, impairing fundus visualisation but not precluding reapplication. Post-operative complications were emulsification in seven case, including one very severe one. No corneal dystrophy and no ocular hypertonia were reported. 

Allergic reactions, alopecia, chest pain, conjunctivitis, diarrhea, diplopia, dizziness, dry mouth, dyspnea, dyspepsia, eye fatigue, hypertonia, keratoconjunctivitis, keratopathy, kidney pain, lid margin crustingor sticky sensation, nausea, pharyngitis, tearing, urticaria... 

Arthralgia, vasodilation, anxiety, hypertonia, nausea, transient chest pain, dyspnea, flu-like symptoms, rash, pruritus Occasional (17%-10%)... 

Choanal atresia with scalp aplasia cutis, umbilical hernia, sacral pilonidal sinus, limb hypertonia, and down-slanting palpebral fissures affected the child of a woman who took methimazole 10 mg/day until the 8th week of gestation (96). 

Most of hyperphenylalaninemia are caused by a mutation in the PAH gene. About 5% of hyperphenylalaninemia is caused by genetic defects in the BH4-metabolizing enzymes, and called malignant-type or atypical hyperphenylalaninemia. Patients with malignant-type hyperphenylalaninemia develop neurological symptoms due to deficiency of catecholamines and serotonin, as well as hyperphenylalaninemia. For example, patients with GTP cyclohydrolase deficiency show severe retardation of development, severe muscular hypotonia of the trunk and hypertonia of extremities, convulsions, and frequent episodes of hyperthermis without infection [160,161]. 

The major clinical uses of atenolol include hypertension angina pectoris acute myocardial infarction (MI) heart rhythm disturbances and migraine prophylaxis. In hypertonia disease, various studies have addressed the efficacy of atenolol in... 

Dystonia, hypertonia, and increased salivation were reported significantly more often in patients taking haloperidol (8.3% versus 0% for the three effects) somnolence (25%), anxiety (12%), and headache (12%) were the most frequent events in patients taking olanzapine. 

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