Aplasia cutis

Aplasia cutis congenita has been attributed to carbima-zole, or its active metabolite thiamazole, given during... 

Additional cases of aplasia cutis congenita in thiona-mide-exposed infants associated with other congenital abnormalities, such as choanal atresia, esophageal atresia, imperforate anus, and cardiovascular defects, were also reviewed. This pattern of abnormalities has previously led to the term methimazole [thiamazole] embryopathy (95). 

Aplasia cutis congenita and choanal atresia have been reported in association with maternal carbimazole therapy, suggesting a causative link either with the drug or with underlying hyperthyroidism. 

Choanal atresia with scalp aplasia cutis, umbilical hernia, sacral pilonidal sinus, limb hypertonia, and down-slanting palpebral fissures affected the child of a woman who took methimazole 10 mg/day until the 8th week of gestation (96). 

Aplasia cutis affected one of twin boys born to a mother with Graves disease, drug addiction, and psychosis, who had taken methimazole 40mg/day, propranolol, and haloperidol (with poor compliance) (96). 

These cases highlight a possible link between carbimazole, or its active metabolite methimazole, and congenital abnormalities, especially aplasia cutis and choanal atresia,... 

Bihan H, Vazquez MP, Krivitzky A, Cohen R. Aplasia cutis congenita and dysmorphic syndrome after antithyroid therapy during pregnancy. Endocrinologist 2002 12 87-91. 

Karg E, Bereg E, Caspar L, Katona M, Turi S. Aplasia cutis congenita after methimazole exposure in utero. Pediatr Dermatol 2004 21(4) 491 1. 

Arevalo-Lorido JC +, firj Clin Pharmacol 55(4), 415 Aplasia cutis congenita Bullous dermatitis... 

Aplasia cutis congenita involving over 90% of body surface area occurred in a baby born to a mother with pemphigus vulgaris who had taken oral prednisolone and azathioprine during pregnancy [140 ]. 

Iftikhar N, Ejaz A, Butt UA, Ali S. Aplasia cutis congenita associated with azathioprine. J Pak Med Assoc 2009 59(11) 782-4. 

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