Hypertension ganglionic blockade

Nowadays a broad spectrum of quite specific blood pressure lowering drugs is available which restricts the use of ganglion blockade. There are only a few situations in which the pharmacological blockade autonomous ganglia is clinically useful hypertensive emergencies, controlled hypotension in neurosurgery and in the treatment of pulmonary edema. 

Experimental results relating to the hypotensive activity of 3 Hiethoxy-V-[4-(4-phenyl-1-piperazlnyl )butoxy ] acetophenone (XIV) as the monohydrochloride (Su-l4542) or dihydrochloride (Su-13396) in normotensive and renal hypertensive dogs have been reported. These were interpreted as indicating that Su-i4542 does not act by ganglionic blockade but does possess... 

Following intravenous injection in the mother, placental transfer of Metubine iodide occurs rapidly, and, after 6 minutes, the fetal plasma concentration is approximately one-tenth the maternal level. Metocurine does not inhibit vagal transmission or sympathetic ganglionic blockade, and therefore produces minimal hemodynamic changes in humans. The relatively stable heart rate and blood pressure associated with its use make it a useful agent for patients with coronary artery disease and hypertension. 

SC-30552 (42) given orally to SHR (spontaneously hypertensive rats) lowered blood pressure and caused bradycardia. Tachycardia caused by isoproterenol was not affected by SC-30552, whereas isoproterenol-induced decreases in blood pressure were attenuated. Ganglionic blockade caused by hexamethonium did not affect vasodilatation caused by this CEB. A pA2 value against calcium-induced contractions of rabbit, aortic strips of 7.42 was calculated. These effects suggest possesses some but not 6i- or a-adrenoceptor activity and may depress the SA node. 

Ganglion blockers - At 10 mg/kg, derivatives of A-azahomoadamantane (Vll) and (VIII) lower the blood pressure of anesthetized dogs by at least 15 for two hours or more, apparently by ganglion blockade.The monomethoxymecamyI amines (IX, R, R, or R CH3O) are about as active as mecamylamine in lowering the blood pressure of renal hypertensive rats, the corresponding hydroxy derivatives are less active. 

Mecamylamine hydrochloride is an antiadrenergic agent that has a potent ganglionic blocking property. It is indicated in the treatment of moderately severe to essential hypertension and uncomplicated malignant hypertension. Blockade of sympathetic ganglia interrupts adrenergic control of arterioles and results in vasodilation, improved peripheral blood flow in some vascular beds, and a fall in blood pressure. 

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