Ganglion-blocking

That is, the pressure is adjusted automatically in response to signals from various baroreceptors. Control of abnormally high pressure can, at least in theory, be achieved by interfering with the chain of transmission of the neural signals that lead to elevation of pressure. Initial success in control of hypertension was met with the ganglionic blocking agents which in effect in-... 

Ganglionic blocking agent. A drug that blocks neurotransmission at the nicotinic receptors of the sympathetic ganglia, thus blocking vascular reflexes. 

A number of years ago, pentamethylpiperidine 55 was found to be a rather potent, though not very specific, ganglionic blocking agent. This finding was of particular interest, as it was at that time believed that a quaternary ammonium function was a... 

Hirsutine. Hirsutine (58) shows ganglion-blocking activity in cat superior cervical ganglion preparation (331), and it has a long-lasting depressive effect (332). Hirsutine also inhibits the ganglionic transmission of the dog urinary bladder (353, 334). 

Kumar R, Reavill C, Stolerman IP (1987) Nicotine cue in rats effects of central administration of ganglion-blocking drugs, Br J Pharmacol 90 239-246 Lamb RJ, Preston KL, Schindler CW, Meisch RA, Davis F, Katz JL, Henningfield JE, Goldberg SR (1991) The reinforcing and subjective effects of morphine in post-addicts a dose-response study. J Pharmacol Exp Ther 259 1165-1173... 

Ganglion blocking (e.g. hexamethonium, pempidine) Blocked Normal Normal Not Yes... 

Spasmolysis by N-butylscopolamine in biUary or renal colic (p. 126). Because of its quaternary nitrogen, this drug does not enter the brain and requires parenteral administratioa Its spasmolytic action is especially marked because of additional ganglionic blocking and direct muscle-relaxant actions. 

D-tubocurarine can induce a release of histamine which results in a massive drop of blood pressure, an increase of saliva and mucus secretion and laryn-gal and bronchospasms, which can interfere with the intubation. In patients with asthma bronchiale on an allergic basis the use of this drug should be avoided. Due to its ganglion blocking properties D-tubocurarine can induce a histamine-independent drop in blood pressure. 

Pain is often episodic, for no obvious reason, and often tends to remit slowly with time. Coeliac ganglion blocking tends to have little or temporary effect, and total pancreatectomy is now seldom undertaken. 

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