3- Hydroxy-p-cymene

Addo trimico 3-p-cymenol p-cymen-3-ol Flavinol 3-hydroxy-p-cymene 3-hydroxy-l-methyl-4-isopropylbenzene Intrasol isopropyl cresol isopropyl-w-cresol 6-isopropyl-m-cresol isopropyl metacresol 2-isopropyl-5-methylphenol 1-methyl-3-hydroxy-4-isopropylbenzene 5-methyl-2-isopropyl-phenol 5-methyl-2-(l-methylethyl) phenol Medophyll thyme camphor thymic acid m-thymol timol. 

Hydroxy-p-cymene. See Thymol 8-Hydroxy-p-cymene a-Hydroxy-p-cymene. See... 

Synonyms 3-p-Cymenol p-Cymen-3-ol 3-Hydroxy-p-cymene 3-Hydroxy-1 -methyl-4-isopropy I benzene Isopropyl cresol 6-lsopropyl-m-cresol Isopropyl-m-cresol Isopropyl metacresol 2-lsopropyl-5-methylphenol 1-Methyl-3-hydroxy-4-isopropylbenzene... 

Synonyms 5-Methyl-2-(l-methylethyl)phenol 3-p-cymenol 3-hydroxy-p-cymene thyme camphor m-thymol isopropylmeta cresol timol Trade names Bensulfold... 

Methyl-2- l-methylethy[)phenol, 9CL p-Mentha-1,3,5-trien-2-ol p-Cymen-3-ol, SCI. 6-Isopropyl-m-cresol. 3-Hydroxy-4-isopropyltoluene. 3-Hydroxy-p-cymene. Thymol, Thymianic acid obsoL). Thymianic camphor (pbsol2) [89-83-8]... 

Pseudomonas sp. strain (PL) was cultivated with p-cymene (178) as the sole carbon source to give cumyl alcohol (192), cumic acid (194), 3-hydroxycumic acid (196), 2,3-dihydroxycumic acid (197), 2-oxo-4-methylpentanoic acid (201), 9-hydroxy-p-cymene (189), and p-cymene-9-oic acid (190) as shown in Figure 19.55 (Madyastha and Bhattacharyya, 1968). On the other hand, p-cymene (178) was converted regiospeci cally to cumic acid (194) by Pseudomonas sp.. Pseudomonas desmolytica, and Nocardia salmonicolor (Madyastha and Bhattacharyya, 1968) (Figure 19.56). 

In conclusion, we have found a convenient and practical method for the selective reduction of C=0 bond of a wide spectrum of a-keto-)S, -unsaturated esters with Ru(p-cymene)(TsDPEN) as catalyst. The transition metal catalyzed transfer hydrogenation reaction with good selectivity and high efficiency offers possibilities to provide the optically active a-hydroxy-/l, y-unsaturated esters with chiral catalysts. Table 3.8 gives different substrates that can be reduced with Ru(p-cymene) (TsDPEN) complex in isopropyl alcohol. 

Limonene (92) is the most widely distributed terpene in nature after a-pinene [68]. The (+)-isomer is present in Citrus peel oils at a concentration of over 90% a low concentration of the (-)-isomer is found in oils from the Mentha species and conifers [26]. The first data on the microbial transformation of limonene date back to the sixties. A soil Pseudomonad was isolated by enrichment culture technique on limonene as the sole source of carbon [69]. This Pseudomonad was also capable of growing on a-pinene, / -pinene, 1-p-menthene and p-cymene. The optimal level of limonene for growth was 0.3-0.6% (v/v) although no toxicity was observed at 2% levels. Fermentation of limonene by this bacterium in a mineral-salts medium resulted in the formation of a large number of neutral and acidic products. Dihydrocarvone, carvone, carveol, 8-p-menthene-1,2-cw-diol, 8-p-menthen-1 -ol-2-one, 8-p-menthene-1,2-trans-diol and 1 -p-menthene-6,9-diol were among the neutral products isolated and identified. The acidic compounds isolated and identified were perillic acid, /Msopropenyl pimelic acid, 2-hydroxy-8-p-menthen-7-oic acid and... 

Ethyl benzoylacetate was hydrogenated with [RuCl2(p-cymene)]2, (S,R)-ephe-drine, and (CH3)2CHOK in 2-propanol to give the S hydroxy ester quantitatively in 94% ee (Scheme 32) [106]. Reduction of methyl 2-acetylbenzoate was performed with the 16-electron Ru catalyst, (S,S)-29 [72], in 2-propanol to afford (S)-3-methylphthalide in 97% ee and in 93% yield contaminated with 1% of 3-(2-isopropoxy)-3-methylphthalide (Scheme 33) [107]. 

SYNS P-CYMEN-3-OL 3-p-CYMENOL 3-HYDRO-XY-p-CYMENE 3-HYDROXY-1-METHYL-4-ISOPROP-YLBENZENE ISOPROPYL CRESOL 6-ISOPROPYL-m-CRESOL 2-ISOPROPYL-5-METHYLPHENOL 1-METHYL-3-HYDROXY-4-ISOPROPYLBENZENE 5-METHYL-2-ISOPROPYL-1-PHENOL 5-METHYL-2-(l-METHYLETHYL)PHENOL THYME CAMPHOR THYMIC ACID m-THYMOL... 

Dipoles (i) phenyl azide (carbon tetrachloride. 25 C) - (ii) C-methyl-(V-phenyl-sydnone (p-cymene, I40°C) (iii) picryl azide (chloroform, 25°C) (iv) anhydro-5-hydroxy-2.4-diphenyl-3-methyloxazolium hydroxide, viz. C.C-diphenyl-N-methyl-miinchnone, (benzonitrile. 50°C) (v) benzonitrile oxide (carbon tetrachloride. 25°C) - " . 

Benzene, (1-methylethenyl)-, homopolymer. See Poly-a-methylstyrene Benzene, 1-methyl-4-(1-methylethy )-. See p-Cymene Benzene monochloride. See Chlorobenzene Benzenenitrile. See Benzonitrile Benzene, pentabromoethyl-. See Pentabromoethylbenzene Benzenephosphonic acid. See Phenyl phosphonic acid Benzenepropanoic acid, 3,5-bis (1,1-dimethylethyl)-4-hydroxy-. See Pentaerythrityl tetrakis [3-(3, 5 -di-t-butyl-4-hydroxyphenyl) propionate] Benzenepropanoic acid, 3,5-bis (1,1-dimethylethy )-4-hydro]qf-, thiodi-2,1-, ethanediyi ester. SeeThiodiethylene bis (3,5-di-t-bulyl-4-hydro) ) hydrocinnamate... 

RuCl(p-cymene)(5)-SunPhos)Cl, ((5)-SunPhos = 270), catalysed the asymmetric hydrogenation of /-heteroatom-substituted )8-keto esters (271) to )/-heteroatom-substituted /3-hydroxy esters (272) with up to 99.1% ee. The optically pure ethyl 4-arylsulfonyl-3-hydroxybutyrate was synthesized for the first time. ... 

Isopropyl-p-cresol (4-Melhyl-2-isoprapyl-plie/iuil, 4 -hydroxy-m-cymene, i-hydroxy-l-meffiyl- - ixirpropylbenzene)... 

The synthesis of benzopyrans has been described by Lam via the alkenylation of 2-aryl-3-hydroxy-2-cyclohexenones followed by oxa-Michael type addition of the enol oxygen atom to the alkenylated intermediate. The reaction requires 2 equiv. of Cu(0Ac)2.H20 in addition to the catalyst [RuCl2(p-cymene)]2 [(Eq. 76)] [159]. The similar reaction using Pd(OAc)2 with Cu(0Ac)2.H20 could be performed for methylvinylketone and phenyl vinyl sulfone [159]. 

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