5-hydroxy-8,10,14-eicosatetraenoic acid 5-HETE

Lagarde M, Gharib A and Dechavanne M, A simple radiochemical assay of thromboxane B2, 12-hydroxy-eicosatetraenoic acid (HETE) and 12-hydroxy-heptadecatrienoic acid (HHT) synthetized by human platelets. Clin. Chim. Acta 79, 255-259, 1977. 

We have already stressed the potential importance of lipid-rich membranes in the skin as potential targets for ROS-induced damage and ageing of human skin is morphologically identical to changes found by peroxidative processes (Serri et al., 1977). The involvement of AA metabolites in skin disease, and in particular psoriasis, has been the subject of much recent interest. Studies have included topical and intradermal administrations of AA metabolites, and assay of such products in clinical specimens. Results show that concentration of AA, 12-hydroxy-eicosatetraenoic acid (12-HETE), PG and leu-kotrienes are increased in psoriatic lesions (Hammarstrom etal., 1975 Camp etal., 1983 Brain etal., 1984 Duell et al., 1988) and also that full-thickness epidermis from normal and diseased skin has the enzymatic capacity to convert AA to some of the same metabolites (Hammarstrom etal., 1975, 1979 Camp etal., 1983 Brain etal., 1984 Ziboh et al., 1984 DueU et al., 1988). The biological effect of both 12-HETE and leukotrienes was confirmed by both topical application and intradermal injection, which caused epidermal inflammation and... 

Temowitz, T., Fogh, K., and Kragballe, K. (1988) Specific Inhibition of Leukotriene B -Induced Neutrophil Chemotaxis by 15-Hydroxy-eicosatetraenoic Acid (15-HETE), Skin Pharmacol. 1, 93-99. 

HERMAN AG, CLAEYS M, MONCADA S, VANE JR Biosynthesis of prostacyclin (PGI2) and 12L-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) by pericardium, pleura, peritoneum and aorta of the rabbit. Prostaglandins 18 439 - 453, 1979. 

Rabbit alveolar macrophages exhibited an apparent discrepancy between the abundance of immu-nospecific cP450 4A protein and no 20-hydroxy-eicosatetraenoic acid production (Zhu et al. 1998). NO generated by alveolar macrophages may auto-inhibit the P450 4A enzymes and production of 20-HETE in these cells. 

Di Marzo, V., Ventriglia, M., MoHo, E., Mosca, M and Cimino, G. (1996) Occurrence and biosynthesis of ll(R)-hydroxy-eicosatetraenoic acid (11-R-HETE) in the Caribbean soft coral Plexaurella dichotoma. Experientia, 52,834-838. 

Previously, we reported the effects of Morus flavonoids on arachidonate metabolism in rat platelet homogenates, such as inhibition of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT), thromboxane B2, and 12-hydroxy -5,8,10,14-eicosatetraenoic acid (12-HETE) [79,80]. As described in the... 

The other metabolic pathway derived from arachidonic acid is through the activity of the lypoxygenase-12 (2-LOX) (Fig. 5). 2-LOX converts arachidonic acid (AA) to 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) that is rapidly reduced by peroxidases to the stable 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE). In... 

Besides 12-LOX in platelets, the 5-LOX isoforms are constitutive in neutrophils. Evidences indicate that LOXs are involved in inflammation diseases and in atherosclerosis. 5-LOX is the enzyme that catalyzes the formation of leukotrienes with potential role for leukocytes and platelets interaction and inflammation. After platelet and leukocyte stimulation, products of both COX-1 and 5-LOX pathways increase. COX-1 activity derivatives increase the vascular permeability mediated by prostaglandins and produce platelet aggregation mediated by TXA2. The product of the lipoxygenase pathway, 5-oxo-6,8,1 1,14-eicosatetraenoic acid (5-Oxo-ETE), induces leukocyte chemotaxis and inflammation. 5-Oxo-ETE is formed by the oxidation of 5S-hydroxy-ETE (5-HETE) by 5-hydroxyeicosanoid dehydrogenase (5-HEDH), a microsomal enzyme found in leukocytes and platelets (42). 

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