5,8,11,14-eicosatetraenoic

Prostaglandins, together with related compounds called thromboxanes and leukotrienes, make up a class of compounds called eicosanoids because they are derived biologically7 from 5,8,11,14-eicosatetraenoic acid, or arachidonic... [Pg.1067]

Eicosatetraenoic acid 5,8,11,14,17-Eicosapentenoic acid 4,7,10,13,16,19-Docosahexenoic acid Tetracosanoic acid 15-Tetracoseanoic acid 2-Hydroxytetracosanoic acid... [Pg.35]

Eicosatetraenoic Arachidonic C20 4 (n = 6) Abundant in animal phospholipids, marine algae and fish... [Pg.388]

It has also been shown that the CYP4 family contains a number of natural substrates appear to be arachidonic acid, the prostaglandins, and/or the leukotrienes. For example, CYP4F2 and CYP4F3, isolated from human liver and human leukocytes, respectively, are leukotriene B4 -hydroxylation of arachidonic acid to form 20-hydroxy-5, 8, 11, 14-eicosatetraenoic... [Pg.68]

Powell PK, Wolf I, Jin R, et al. Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver involvement of CYP4F2 and CYP4A11. J Pharmacol Exp Ther 1998 285(3) 1327-1336. [Pg.106]

An intravenous infusion of PAF causes rapid (within 60 s) intravascular platelet aggregation, thrombocytopenia and platelet factor 4 release, as well as a profound and reversible neutropenia, due to enhanced aggregation and adherence of these cells. In vitro, PAF effects on neutrophils are dependent upon extracellular Ca2+ and Mg2+ and occur within 60 s of addition. The addition of inhibitors of 5-lipoxygenase activity (e.g. ETYA, 5,8,11,14-eicosatetraenoic acid and NDGA, nordihydroguaiaretic acid) - but not those... [Pg.86]

Sodium 5,8,11,14-eicosatetraenoate, 3809 Sodium ethoxyacetyMe, 1478 1,1,2,3 -Tetrachloro-1,3-butadiene, 1389 t Tetrahydrofman, 1612... [Pg.312]

Prostaglandins (PG s) and leukotrienes (LT s) are biologically active derivatives of 20 carbon atom polyunsaturated essential fatty acids, which contains 3, 4 or 5 double bonds (e.g. 5,8,11,14-eicosatetraenoic acid i.e., arachidonic acid). [Pg.225]

Arachidonic acid (5,8,11,14-eicosatetraenoic acid), a polyunsaturated fatty acid derived from dietary sources or by desaturation and chain elongation of the essential fatty acid linoleic acid, is found widely in the body. It is transported in a protein-bound state and stored in the phospholipids of cell membranes in all tissues of the body [108] from where it can be changed into biologically... [Pg.260]

Sodium 5,8,11,14-eicosatetraenoate, 3803 Sodium ethoxyacetylide, 1474 1,1,2,3-Tetrachloro-1,3-butadiene, 1385 f Tetrahydrofuran, 1607 Tetrahydronaphthalene, 3294 f Tetrahydropyran, 1959 Tridecanal, 3613 f Vinyl acetate, 1527 f 4-Vinylcyclohexene, 2999 See Indane-2-aldehyde ACETYLENIC COMPOUNDS ALKALI METALS ALKENES ALKYNES... [Pg.2526]

Arachidonic acid (AA) 20 4 cis,cis,cis,cis-5,8,11, 14-eicosatetraenoic acid Liver fats... [Pg.94]

Arachidonic acid 5,8,11,14-Eicosatetraenoic acid 20 Liver, brain... [Pg.9]

Purification of arachidonic acid (5,8,11,14-eicosatetraenoic acid) Peroxides are removed from commercially available arachidonic acid by addition of 15 mg of sodium borohydride to 100 mg fatty acid dissolved in 3 ml toluene. The mixture is incubated for 30 min with occasional stirring before addition of 3 ml water and 0.7 ml 1 M citric acid. After vortex-mixing, the phases are separated and the organic phase removed and washed with 1 ml of water. Peroxide free arachidonic acid is dried over anhydrous sodium sulphate and stored at 4°C after addition of 2 ml of 10 mM BHT. [Pg.142]

Eicosanoid (Section 27.4) A lipid derived biologically from 5,8.11,14-eicosatetraenoic add, or arachidonic acid. Prostaglandins, thromboxanes and leukotrienes are e.xamples. [Pg.1240]

The leukotrienes are members of the eicosanoid family of phospholipid mediators. Their name derives from the fact that leukotrienes are found in leucocytes and contain a triene system of double bonds. The other members of the eicosanoid family are the prostanoids (thromboxanes and the prostaglandins), and these are formed by the cyclooxygenase system see cyclooxygenase inhibitors. All the eicosanoids are derived mainly from arachidonic acid (5,8,11,14-eicosatetraenoic acid). These mediators are synthesized on demand, and in some cases their half-lives are short. [Pg.166]

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