2-Hydroxy-4- -3,6-dimethylbenzoic

Men who were exposed to a mist of a specific type of Finnish white spirits used for washing cars (Pfaffli et al. 1985) had elevated levels of dimethylbenzoic acid, a metabolite of trimethylbenzene, in their urine following the workshift. This study attempted to quantify exposure to white spirits through the analysis of dimethylbenzoic acid isomers, which are easily detected markers. It assumed that being in a mixture does not affect the metabolism of trimethylbenzene or any of the other constituents of Stoddard solvent. The amount excreted was linearly related to the estimated exposure level. The composition of the white spirits in this study included 11% aromatics with 1% trimethylbenzene isomers, which is similar to the compositions of Stoddard solvent used in the United States. A correlation between exposure to 1,2,4-trimethylbenzene, a component of white spirits, at the TLV- TWA (25 ppm), and the urinary concentration of 3,4-dimethylhippuric acid (3,4-DMHA) was reported in ceramics workers (Fukaya et al. 1994). Rats were dosed by gavage with t-butylcyclohexane (800 mg/kg), another component of white spirits, and seven compounds were identified as urinary metabolites (Flenningsen et al. 1987). The primary metabolite was trans-4-t-butylcyclohexanol, with lesser amounts of 2 "-hydroxy-4t-butylcyclohexanol, 2-methyl-2-cyclohexylpropanoic acid, 2 "-hydroxy- 4 "-t-butylcyclohexanol, 2-methyl-2-cyclohexy 1-1,3-propanediol, 2-hydroxy-4-butylcyclohexanol, and Cis-4-t- butylcyclohexanol also being detected. Rats that had a white spirit formulation (690.8 mg/kg) applied to their tails 5 days/week for 6 weeks were reported to have excreted several products (dimethylbenzoic acid isomers) of trimethylbenzene metabolism in their urine. 

Dihydroxy-6-methylbenzoyl)oxy]-2-hydroxy-3,6-dimethylbenzoic acid. Norisoobtusatic acid [132396-90-8]... 

New polyesters have been synthesized from 4-hydroxy-3,5-dimethylbenzoic acid and condensation polymers derived from squaric acid have been reviewed. ... 

Ethyl 5-methyl-isoeverninate, Ethyl 2-methoxy-4-hydroxy-5,6-dimethylbenzoate... 

Hydroxy-p-orcinolcarboxylic acid, 2,4,5-Trihydroxy-3,6-dimethylbenzoic acid... 

Blaser D, Gunzinger J, Stocklin-Evans H, Tabacchi R (1992) Structure of 2-methoxy methyl P-orcinol carboxylate (methyl 4-hydroxy-3,6-dimethylbenzoate). Acta Crystallogr C 48 1126-1127... 

I9H1gOa, 11-Hydroxy-3-methyl-1,4,4a,12a-tetrahydronaphthalene-5,12-quinone, 45B, 163 C20H16, 1,12-Dimethylbenz[alanthracene, 44B, 164 CaoHiSf 1,12-Dimethylbenzo[clphenanthrene, 28, 446 C20H16, 9,10-Dimethyl-1,2-benzanthracene, 24, 672 29, 696 C20H1eOs r 7,8-Dihydro-1,6-dimethoxy-5,10,12(9H)-naphthacenetrione, 45B, 164... 

Haematomma ochrophaeum benzoic acid and methyl 4-hydroxy-2-meth-oxy-3,6-dimethylbenzoate with TFAA (96) ... 

From benzyl 4-hydroxy-2-methoxy-6-n-propylbenzoate and 2-benzyloxy-4-methoxy-6-/i-propylbenzoic acid with TFAA and subsequent deboizylation From 2,4-dibenzyloxy-5-chloro-3,6-dimethylbenzoic acid and methyl 2,4-dihydroxy-3,5,6-trimethylboizoate with TFAA and subsequent debenzylatiMi 94... 

From 5-formyl-2,4-dihydroxy-3,6-dimethylbenzoic acid and 4-hydroxy-2-methoxy-3,5,6-trimethylbenzoate with TFAA... 

From 2,4-dibenzyloxy-3,6-dimethyl-benzoate and benzyl 4-hydroxy-2-methoxy-3,6-dimethylbenzoate with TFAA and subsequent debenzylation From 2,4-dibenzyloxy-6-n-pentylbenzoic acid and benzyl 2,3-dihydroxy-4-methoxy-6-n-pentylbenzoate with TFAA and subsequent debenzylation... 

Dipropylacetylsalicylic acid was found to have a more intense and longer lasting analgesic activity than the same dose of acetylsalicylic acid . Faye and co-workers reported that 2-hydroxy-3,6-dimethylbenzoic acid and its 6-isopropyl derivative have more analgesic effect in the rat than acetylsalicylic acid. 

After initial metabolism, most of the detoxified portion of PAH compounds are excreted into the bile as metabolites, then subsequently eliminated in the faeces. A smaller proportion is excreted in urine. The two major metabolites of benzo( )pyrene found in urine are 3-hydroxy- and 9-hydroxybenzo(o)pyrene, part of them being conjugated to sulphate or glucuronic acid (Bouchard and Viau, 1997 Ramesh et al., 2001). The process of excretion of PAH compounds into the intestine via the bile, reabsorption, and return to the liver by the portal circulation (enterohepatic recirculation) has been demonstrated to occur for 7,12-dimethylbenzo( )anthracene, benzo(o)pyrene, anthracene and pyrene (Ramesh et al., 2004). Enterohepatic circulation extends the residence time of PAHs in the body and may lead to long half-lives of reactive PAH metabolites. Though enterohepatic recycling of PAHs has... 

Carboxy-4-hydroxy-5-methyl phenyl) 3-carboxy-5-methyl-4-oxo-2,5-cyclohexadien-l-ylidene)methyl -6-hydroxy-2,4-dimethylbenzoic acid, 9CI. C.I. Mordant violet 33. C.I. 43870 [2305-53-5]... 

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