Hydrotropic polymer properties

While the structure of the hydrotropic moiety of the polymer is the most important factor in hydrotropy, other factors can also contribute to the overall hydrotropic property of the polymers. The spacer between the polymer backbone and the hydrotropic moiety is one key factor affecting the overall hydrotropy. Two different hydrotropic polymers based on V-PNA have different hydrotropic properties depending on the nature of the spacer. The paclitaxel solubility in P(6-VBOPNA) increased to a larger extent than in poly(6-allyloxy-V-PNA) (P(6-APNA)), where the aromatic spacer was replaced with a linear chain. 

Because hydrotropic polymers can be diluted when introduced into aqueous solution, cross-linked hydrotropic polymers, i.e., hydrotropic hydrogels, were prepared. Hydrotropic hydrogels are prepared by polymerization of hydrotropic monomers in the presence of cross-linking agents. Despite the cross-linking of linear hydrotropic polymer chains, the hydrogels maintained the hydrotropic property. The hydrotropic hydrogel... 

Poor water solubility of drugs and new chemical entities presents major challenges in the development of clinically useful formulations. Of the various approaches used for enhancing the solubility of poorly soluble drugs, polymeric delivery systems have been used effectively. Paclitaxel has been used as a model hydrophobic drug to show the effectiveness of solubility-enhancing properties of various polymeric delivery systems. Recently, hydrotropic polymers were developed based... 

Uses Hydrotrope, stabilizer, solubilizer used in formulating detergents, inks, electroplating baths, dyestuffs, polymers Properties Klett 50 max. liq. dens. 10.2 Ib/gal pH 7-9 40% min. act. 

It is important to ensure that the modified forms, both monomers and polymers, of hydrotropic agents maintain their hydrotropic properties. Fig. 5A shows the enhancement of aqueous solubility of paclitaxel as a function of the concentration of 2-VBOPNA, 6-VBOPNA, and PNA. Two monomers, 2-VBOPNA... 

Part Two, Surfactants, contains chapters on the four major classes of surfactants, i.e. anionics, nonionics, cationics and zwitterionics, as well as chapters on polymeric surfactants, hydrotropes and novel surfactants. The physico-chemical properties of surfactants and properties of liquid crystalline phases are the topics of two comprehensive chapters. The industrially important areas of surfactant-polymer systems and environmental aspects of surfactants are treated in some detail. Finally, one chapter is devoted to computer simulations of surfactant systems. 

The properties of the slurry and the subseqnent blown powder are dominated by the interaction of the LAS, which forms a liquid crystalline phase with the other ingredients within the slurry. Consequently, small quantities of some minor ingredients such as polymers, hydrotropes, and cosurfactants can have a significant effect on the slurry properties such as its rheology, and therefore, the amount of water required in the crutcher mix. 

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