Hydrotropic monomers

Hydrotropic copolymers can also be synthesized using two different hydrotropic monomers. The concept... 

Fig. 4 Various hydrotropic monomers (A), and an exemplary synthetic scheme of a hydrotropic polymer, poly(2-(4-vinylbenzyloxy)-V-picolylnicotinamide) P(2-VBOPNA)] (B).

Because hydrotropic polymers can be diluted when introduced into aqueous solution, cross-linked hydrotropic polymers, i.e., hydrotropic hydrogels, were prepared. Hydrotropic hydrogels are prepared by polymerization of hydrotropic monomers in the presence of cross-linking agents. Despite the cross-linking of linear hydrotropic polymer chains, the hydrogels maintained the hydrotropic property. The hydrotropic hydrogel... 

It is important to ensure that the modified forms, both monomers and polymers, of hydrotropic agents maintain their hydrotropic properties. Fig. 5A shows the enhancement of aqueous solubility of paclitaxel as a function of the concentration of 2-VBOPNA, 6-VBOPNA, and PNA. Two monomers, 2-VBOPNA... 

---