Hydrolases inhibition

McElroy NR, Jurs PC, Morisseau C, Hammock BD. QSAR and classification of murine and human epoxide hydrolase inhibition by urea-like compounds. J Med Chem 2003 46 1066-80. [Pg.467]

Justinova, Z., Manieri, R. A., Bortolato, M., Chefir, S. I., Mukhin, A. G., Clipper, J. R., King, A. R., Redhi, G. H., Yasar, S., Pomelli, D., and Goldberg, S. R. (2008). Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. [Pg.69]

Palmer JA, Higuera ES, Chang L, Chaplan SR (2008) Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. Neuroscience 154 1554-1561... [Pg.516]

Quistad, G.B., Sparks, S.E., Casida, J.E. (2001). Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides. Toxicol. Appl. Pharmacol. 173 48-55. [Pg.89]

Both the toxicodynamics and toxicokinetics of OP nerve agents can be explained by their biochemical characteristics of interacting with cholinesterases and other hydrolases. Inhibition of cholinesterases in the blood is the first target for OPs according to the principle of first come, first served (Benschop and de Jong, 2001). [Pg.877]

Morisseau C, Du G, Newman JW, Hammock BD. Mechanism of mammalian soluble epoxide hydrolase inhibition by chalcone oxide derivatives. Arch Biochem Biophys 1998 356 214-28. [Pg.431]

L. Orning, G. Krivi, F.A. Fitzpatrick, Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes, J. Biol. Chem. 1991, 266,1375-1378. [Pg.848]

Acetylcholinesterase (AchE) hydrolyses the neurotransmitter acetylcholine and yields acetic acid and choline. AchE is a serine hydrolase inhibited by organophosphorus poisons, as well as by carbamates and sulfonyl halides which form a covalent bond to a serine residue in the active site. AchE inhibitors are used in the treatment of various disorders. ... [Pg.63]

Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Ealck JR, Gutterman DD (2006) Epoxyeieosatrienoie and dihydroxyeicosa-trienoic acids dilate human coronary arterioles via BK(Ca) channels implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol 290 H491-499... [Pg.899]

Fang X, Kaduce TL, Weintraub NL, Harmon S, Teesch LM, Morisseau C, Thompson DA, Hammock BD, Spector AA (2001) Pathways of epoxye-icosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. J Biol Chem 276 14867-14874... [Pg.901]

Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD (2007) Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins Other Lipid Medial 82 42-49... [Pg.901]

Motoki A, Merkel MJ, Packwood WH, Cao Z, Liu L, Ilifif J, Alkayed NJ, Van Winkle DM (2008) Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfu-sion injury in vivo. Am J Physiol Heart Circ Physiol 295 H2128-H2134... [Pg.903]

Ilifif JJ, Alkayed NJ (2009) Soluble epoxide hydrolase inhibition targeting multiple mechanisms of ischemic brain injury with a single agent. Future Neurol 4 179 199... [Pg.903]

Mechanism of Mammalian Soluble Epoxide Hydrolase Inhibition by Chalcone Oxide Derivatives. [Pg.407]

Deazaadenosine an inhibitor of adenosylhomocysteine hydrolase Inhibits reproduction of Rous sarcoma virus and transformation of chick embryo cells. Virology 89 494 (1978). [Pg.80]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...