Structure-based hybridization

The self-arranged ordered DNA structures decorated by Ag nanoparticles are effectively formed on the Si surface modified by APTES. The investigations have shown the commonalities and some specific features in the hybrid structures on smooth mica surface and modified Si substrates. Small number of regular structures on mica surfaces proved that binding force of DNA to the surfaces is much lower in mica-DNA system as compared to the hybrid structure based on modified Si substrates. Spectroscopic ellipsometry measurements have shown the contributions to optical response due to components in hybrid samples. 

V. HYBRID STRUCTURES BASED ON OLIGONUCLEOTIDES THAT CONTAIN TERMINAL LIGANDS... 

Figure 3. Hybrid structures based on coordination complexes and nucleic acids.

Ozkan, S. Zh., Dzidziguri, E. L., Krpacheva, G. R, Bondarenko, G. N. Metal-polymer nanocomposites based on polydiphenylamine and copper nanoparticles synthesis, structure and properties. Russian Nanotechnologies. 2011, Vol. 6. Na 11-12,78-83. Karpacheva, G., Ozkan, S. Polymer-metal hybrid structures based on polydiphenylamine and Co nanoparticles. Procedia Materials Science. 2013, V. 2,52-59. 

Varady J, Wu X, Fang X, Min J, Hu Z, Levant B, Wang S. Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor discovery of novel and potent D3 ligands through a hybrid pharmacophore-and structure-based database searching approach. / Med Chem 2003 46 4377-92. 

Keywords VS, Virtual Screening, Lead discovery, lead, HTS, Pharmacophore-Based, Structure-Based, Fragment-based, Ligand-based, Docking, Scoring, hybrid workflows, VS strategy, Benchmarking VS... 

FIGURE 4.1 Molecular structure based on hybrid orbital type. 

Besides the use of solution-based processing for the deposition of inorganic compounds, major developments are taking place in the field of deposition of organic-inorganic hybrid structures. Already indicated was the use of a combination of structured inorganic QDs and organics in the field of photovoltaics,... 

Azo pigments carry an azo function (—N=N—) between two sp2-hybridized C atoms. They are structurally based on the general formula... 

The polymer/SWCNT composites can be used as Scaffolds in tissue engineering. The donor-acceptor interactions can be used to assemble thin polymer/SWCNT films stepwise. This method also can be expended to more thermally and oxidatively stable polymer systems. For example, the P4VP/SWCNT films can be used as scaffolds for the synthesis of novel hybrid structures (Correa-Duaite et al., 2004). The polyethyl-enimine (PEI)-SWCNTs composites were used as a substrate for cultured neurons, and promoted neurite outgrowth and branching (Rouse et al., 2004). Correa-Duarte et al. (2004 Landi et al., 2005) reported that 3D-MWCNT-based networks are ideal candidates for scaffolds/matrices in tissue engineering. 

Many condensation polymers are also named in this manner. In the case of poly(ethylene terephthalate), the glycol portion of the name of the monomer, ethylene glycol, is used in constructing the polymer name, so that the name is actually a hybrid of a source-based and a structure-based name. 

Benzene, CgHg, is a common industrial solvent. The benzene molecule is based on a ring of covalently bonded Ccirbon atoms. Draw two acceptable Lewis structures for benzene. Based on the structures, describe a likely resonance hybrid structure for benzene. 

Kim et al. used the exchange reaction to synthesize cross-linked AuNP-PNIPAM core-shell hybrid structures, as well as a brush-type AuNP/PNIPAM hybrid through surface-initiated ATRP in an aqueous medium. The disulfide initiators, [BrC (CH3)2COO(CH2)iiS]2, were bound to AuNPs synthesized by citrate reduction. They have studied the effect of cross-linking on the thermo-responsiveness of the AuN / PNIPAM hybrids for potential use as a stimuli responsive optical device, such as surface plasmon resonance-based sensing materials [91]. 

Qi, Y.-F., Li, Y.-G., Wang, E. et al. (2007) Hydrothermal synthesis and structures of organic-inorganic hybrid solids based on arsenic-vanadate building blocks. Journal of Coordination Chemistry, 60(13), 1403-18. 

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