Hyaluronic derivatives

Vercruysse, K. P. and G. D. Prestwich. 1998. Hyaluronate derivatives in drug defiJrelryRev. Ther. Drug Carrier Syst.15 513-555. 

Vercruysse, K.P. and Prestwich, G.D., Hyaluronate derivatives in drug dehvery, Crit. Rev. Therapeut. Drug Carrier. Sysl., 15, 513, 1998. 

Vercruysse KP, Prestwich GD. Hyaluronate derivatives in drug delivery. Crit Rev Ther Carrier Syst 1998 15 513-555. 

Davidson JM, Nanney LB, Broadley KN, Whitsett JS, Aquino AM, Beccaro M, Rastrelli A. Hyaluronate derivatives and their application to wound heahng preliminary observations. Clin Mater 1991 8 171-177. 

Gerard, C., Catuogno, C., Amargier-Huin, C., et al., 2005. The effect of alginate, hyaluronate and hyaluronate derivatives biomaterials on synthesis on non-articular chondrocyte extracellular matrix. 1. Mater. Sci. Mater. Med. 16, 541-551. 

Typical spectra obtained are shown in Fig. 1.2. Moreover, substantial radiolytically-mediated elevations in the concentration of serum formate, arising from the oxidation of carbohydrates present by OH radical, were also detectable. In addition to the above modifications, 7-radiolysis of inflammatory knee-joint synovial fluid generated an oligosaccharide species of low molecular mass derived from the radiolytic fragmentation of hyaluronate as outlined in the previous section dealing with oxidative damage to carbohydrates. The... 

JA Hunt, HN Joshi, VJ Stella, EM Topp. Diffusion and drug release in polymer films prepared from ester derivatives of hyaluronic acid. J Controlled Release 12 159-169, 1990. 

Hyaluronic Add Sulfate.—Meyer and Chaffee108 showed that this mucopolysaccharide of the cornea was a true derivative of hyaluronic acid, since it could be hydrolyzed enzymically by what is now known as hyaluronidase. ... 

Knowing that nitric oxide and hyaluronic acid both play an important role in the wound healing process, Di Meo et al. chose to combine the properties of both entities and synthesized new NO-donors based on hyaluronic acid derivatives exhibiting a controlled NO-release under physiological conditions (in vitro tests). These derivatives were fully characterized by and 13C NMR spectroscopy and their NO release monitored by means of UV spectrophotometric measurements.47... 

THERMODYNAMICS OF WATER SORPTION IN HYALURONIC ACID AND ITS DERIVATIVES... 

Thermodynamics of Water Sorption in Hyaluronic Acid and Its Derivatives... 

PMNs also produce oxygen-derived free radicals when exposed in vitro to chrysotile or crocidolite. The highly reactive superoxides could injure other cells or attack extracellular matrix molecules. Hyaluronic acid (part of the mucopolysaccharide molecule) is a particularly vulnerable matrix species, but the specific reaction mechanisms have not been elucidated. 

Acetamido-2-deoxy-D-glucose is a component of a mucopolysaccharide hyaluronic acid. It has been demonstrated, by PET imaging with the corresponding F labeled compound, that this glucose derivative is incorporated into the connective tissue at the interface of a tumor and healthy tissue. Thus, it can be used as a tumor label. 6-[ F]-6-Deoxy-L-ascorbic acid also deserves attention, as it maintains the antioxidant properties of ascorbic acid. Thus, it can be useful to smdy the biochemical... 

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