Humans sex hormones

IARC Monographs on The Evaluation of the Carcinogenic Risk of Chemicals to Humans, Sex Hormones, Vol. 21 (International Agency for Research on Cancer, Lyon, 1979). 

Cherkasov, A., Shi, Z., Fallahi, M., and Hammond, G.L. (2005) Successful in silico discovery of novel non-steroidal ligands for human sex hormone binding globulin. J. Med. Chem. 48, 3203-3213. 

D GanBer, G Spiteller. Plant constituents interfering with human sex hormone-binding globulin. Evaluation of a test method and its application to Urtica dioica root extracts. Z Naturforsch C Biosci 50 98-104, 1995. 

M Schottner, D GanBer, G Spiteller. Lignans from the root of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Medica 63 529-632, 1997. 

Danzo, B. J., and D. R. Joseph. 1994. Structure-function relationships of rat androgen binding protein/human sex-hormone binding globulins The effect of mutagenesis on steroidbinding parameters. Endocrinology 135 157-167. 

Adolph Butenandt, who shared the 1939 Nobel Prize in chemistry for isolation and structure proofe of human sex hormones, was intrigued by the highly specific attraction of female moths for male moths at great... 

Bauer, E.R.S., Daxenberger, A., Petri, T., Sauerwein, H., and Meyer, H.H.D., Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine gestagen receptor, APMIS, 108, 838-846, 2000. 

Cholesterol, an integral part of animal membranes, is the compound from which human sex hormones, adrenocorti-coid hormones, bile acids, and vitamin D are synthesized. 

Human sex hormones are steroids that regulate tissue growth and reproductive processes. Male sex hormones are called androgens, and there are two types of female sex hormones called estrogens and progestins. Table 26.3 shows the most important male and female sex hormones. 

Steroid molecules have four rings three cyclohexane rings and one cyclopentane ring (Section 22.4). Progesterone (top) and testosterone (bottom) also have ketone functional groups. Both molecules are human sex hormones. 

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