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Human P450 genes

Inoue, K., Borchers, C.H. and Negishi, M. (2006) Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics. The Biochemical Journal, 398, 125-133. [Pg.462]

As with some of the other human P450 genes, the only information presently available is the identification of the CYP2U1 gene in the human genome . [Pg.423]

Recombinant DNA technology allowed for insight into the regulation of human P450 genes and also for the analysis of single nucleotide variations (SNVs), which could sometimes be associated with altered drag or steroid metabolism... [Pg.524]

Each of the 57 human P450 genes/gene products will be covered here. Clearly much more information is available about some than others. Points to be covered with each, when possible, include sites of expression and relative abimdance, regulation, genetic variation, substrates and reactions, stracture, inhibitors, and clinical issues. It must be emphasized that this chapter is not intended to be comprehensive, and the literature accumulates rapidly the reader is encouraged to do further literature searches for each P450 of interest. [Pg.553]

Rozman and her associates have analyzed genetic variations and reported that the P450 51A1 gene contains fewer variants than any other human P450 gene [2746, 2747], This may be related to the importance of this enzyme i.e., abnormalities might be lethal. [Pg.669]

Production of Transgenic Rice Plants Expressing Human P450 Genes... [Pg.19]

Gonzalez FJ, Nebert DW. Evolution of the P450 gene superfamily animal-plant warfare , molecular drive, and human genetic differences in dmg oxidation. Trends Genet 1990 6 182-186. [Pg.510]

Pascussi JM, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ (2000b) Dexamethasone enhances constitutive andros-tane receptor expression in human hepato-cytes consequences on cytochrome P450 gene regulation. Mol Pharmacol 58, 1441-1450. [Pg.322]

Hayashi S, Watanabe J, Nakachi K, et al. 1994. Interindividual difference in expression of human Ah receptor and related P450 genes. Carcinogenesis 15 801-806. [Pg.630]

Heim HM, Meyer UA. Evolution of a high polymorphic human cytochrome P450 gene cluster CYP2D6. Genomics 1992 14 49-58. [Pg.66]

Bowen WP, Carey J, Miah A, et al. Measurement of cytochrome P450 gene induction in human hepatocytes using quantitative real-time reverse transcriptase-polymerase chain reaction. Dmg Metab Dispos 2000 28 781-788. [Pg.229]

Schwarz UI (2003) Clinical relevance of genetic polymorphisms in the human CYP2C9 gene. Eur J Clin Invest 33 23-30 Scordo MG, Aklilln E, Dahl ML et al. (2001) Genetic polymorphism of cytochrom P450 2C9 in a Caucasian... [Pg.724]

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P450 genes

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