Human metapneumovirus

Tang Y-W, Crowe JE Jr (2007) Respiratory syncytial virus and human metapneumovirus. In Murray PR (ed) Manual of clinical microbiology, 9th edn. ASM Press, New York... 

Wyde PR, Moylett EH, Chetty SN et al (2004) Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by NMS03 in tissue culture assays. Antiviral Res 63 51-59... 

Greensill, J., McNamara, P. S., Dove, W., Flanagan, B., Smyth, R. L., and Hart, C. A. (2003). Human metapneumovirus in severe respiratory syncytial virus bronchiohtis. Emerg. Infect. Dis. 9, 372. 

Fig. 6.2.6. Human metapneumovirus pneumonia in a 58-year-old man with neutropenia following HSC transplantation. Transverse thin-section (1-mm collimation) CT scan obtained at level of the carina shows bilateral areas of ground-glass attenuation and multiple ill-defined nodules affecting the posterior segment of the right upper lobe and both superior segments of the lower lobes...

Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Cote S, Peret TC, Erdman DD, Anderson LJ (2002) Virological features and clinical manifestations associated with human metapneumovirus a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis 186 1330-1334... 

Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, Wright PF, Crowe JE Jr (2004) Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 350 443-450... 

Many enveloped viruses share a common mechanism of fusion, mediated by a virus-encoded glycoprotein that contains heptad repeats in its extraceUnlar domain. Dnring the fnsion process, these domains rearrange to form highly structured and thermodynamically stable coiled-coils. Viruses encoding fusion proteins that have these domains inclnde members of the paramyxovirus family (e.g., respiratory syncytial virus, metapneumovirus, and measles virus), ebola virus, influenza, and members of the retroviridae (e.g., human T cell lenkemia virus type-1 and human immunodeficiency virus type-1, HlV-1). Peptide inhibitors of fusion that disrupt the... 

Respiratory syncytial virus is a member of the paramyxovirus family, a genera that includes metapneumovirus, measles and Newcastle disease viruses [21]. The discovery of RSV as a human pathogen began with an outbreak of coryza in chimpanzees, documented in 1956, which was quickly followed by the identification of the vims in infants presenting with bronchiolitis and pneumonia [22-25]. Epidemiological studies have established the patterns of outbreaks of RSV... 

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