Human leucocyte antigens HLA

The human leucocyte antigen (HLA) system is the general name of a group of genes in the human major histocompatibility complex (MHC) region on human chromosome 6 (mouse chromosome 17) that encodes the cell-surface antigen-presenting proteins. 

Genes encoding particular class II Human Leucocyte Antigens (HLA) are among candidates for involvement in predisposition to RA. This discovery came about with the observation that 60- 70% of Caucasian patients with RA are HLA-DR4 positive by... 

The group of Hunt [1] pioneered the identification of trace-level peptides in complex biological samples by means of microcapillary reversed-phase RPLC-MS-MS in the analysis of endogenous human class I major histocompatibility complex (MHC) encoded human leucocyte antigen (HLA-A2.1) peptides. 

Several risk factors for the development of OB/BOS have been identified, that can be subdivided into immunological and nonimmunological risk factors. Late or recurrent/refractory acute rejection and lymphocytic bronchitis/bronchiolitis were the most convincing (16), which together with repeated Ai acute rejection, noncompliance, human leucocyte antigen (HLA) mismatches at the A locus and total HLA mismatches, constitute the immunological risk factors (17). 

---