Human Herpes Virus 6 HHV

Human herpes virus 8 (HHV-8) Activation of oncogenes and expression of a virally encoded VEGF receptor Flaitz and Hicks [63]... 

The exact nature of the disease is not clear, hut current data support a tight link to human herpes virus 8 (HHV-8) infection (Iscovich et al. 2000). 

Still, there is a clear relation to viral infection in many cases of LIP, especially in children. In fact, there appears to be an association between LIP and several different viral infections. The culprits include Epstein-Barr virus (EBV), HIV-1, and human herpes virus-8 (HHV-8). 

Many other viral infections, including the ones most threatening to humans, like hepatitis C, B, and A viruses (HCV, HBV, HAV), human papillomavirus viruses (HPVs), West Nile virus, and human herpes viruses (i.e., HSV, CMV, EBV, and HHV-8) are also the targets of intense research for the development of effective RNAi treatments. It has been demonstrated that RNAi can disrupt the replication of many viruses, including HCV, HBV, and HAV in cell culture [99,100] and, as later demonstrated in mouse models, in vivo [101,102]. The major limitation, again, is the delivery and stability of RNAi compounds for application as human therapies in clinically relevant systems, which will be discussed further below. These examples demonstrate, however, that RNAi technology has great potential for the treatment of viral disease, yet clearly requires further development for clinical applications. 

There are eight members of the herpesvirus family able to infect humans HHV-1 (herpes simplex virus 1, HSV-1) HHV-2 (herpes simplex virus 2, HSV-2) HHV-3 (varicella zoster virus,VZV) HHV-4 (Epstein-Barr virus, EBV) HHV-5 (cytomegalovirus, CMV) HHV-6 (human B-cell lymphotrophic virus or roseolovirus) HHV-7 (closely related to HHV-6) HHV-8 (a type of the rhadinovirus). 

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