Human blood coagulation

R. G. Macfadane, in R. Biggs, ed.. Human Blood Coagulation, Haemostasis and Thrombosis, 2nd ed., Blackwell Scientific PubHcations, Oxford, 1976, pp. 1-31. 

Herzog, R. W., Hagstrom, J. N., Rung, S. H., Tai, S. J., Wilson, J. M., Fisher, K. J. and High, K. A. (1997). Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc. Natl. Acad. Sci. USA 94, 5804-5809. 

Naito K, Fujikawa K, Activation of human blood coagulation factor XI independent of factor XII factor XI is activated by thrombin and factor Xia in the presence of negatively charged surfaces. J Biol Chem 1991 66 7353-7358. 

K. Kamata, H. Kawamoto, T. Honma, T. Iwama, S. H. Kim, Stmctural basis for chemical inhibition of human blood coagulation factor Xa. Proc. Nad. Acad. Sci. USA 1998, 95, 6630-6635. 

Amatschek K, Necina R, Hahn R, Schallaun E, Schwinn H, Josic D, and Jungbauer A. Affinity chromatography of human blood coagulation factor VIII on monoUths with peptides from a combinatorial Ubrary. J. High Resol. Chromatogr. 2000 23 47-58. 

Jack Levin, who had an interest in the effects of endotoxin on platelets and human blood coagulation, joined Bang at Woods Hole, MA, for several summers to do research on endotoxin-initiated Limulus blood coagulation. This collaboration produced several publications that explained a simple mechanism of enzyme-mediated interaction of LAL with endotoxin. " " Levin discovered a way to harvest the intracellular fluid by osmotic lysis of stabilized amebocytes. Modern-day preparation of LAL reagent still follows Levin s basic methods. 

Trials of gene therapy in hemophilia A and B, to determine safety and efficacy, are under way (2). Three patients with hemophilia B were treated in a phase I trial with a recombinant adenovirus-associated vector expressing human blood-coagulation factor IX (3). There was no evidence of formation of inhibitory antibodies against factor IX. In a phase I trial with a recombinant adenovirus-associated vector expressing human blood-coagulation factor IX, there was no evidence of germ-line transmission of vector sequences (3). 

Hooker B, Dai Z, Gao J, et al., inventors Transgenic Plant-derived Human Blood Coagulation Factors. 1999. PCT-World Intellectual Property Organization WO 99/58699. 

Amfilochiadis A A, Papageorgiou P C, Kogan N, et al. (2004). Role of bradykinin B2-receptor in the sympathoadrenal effects of new pressor protein related to human blood coagulation factor XII fragment. 7. Hypertens. 22 1173-1181. 

R. Biggs and R. G. Macfarlane, Human Blood Coagulation, F. A. David Company, Philadelphia (1962). 

Human interferon-o2a, interleukin-2 receptor, human IgG, human serum albumin, dehydrogenases glucose-6-phosphate dehydrogenase, foanate dehydrogenase, pyruvate decarboxylase, S-oxynitrilase, bovine liver catalase, recombinant protein G, plasmid DMA, human blood coagulation factor VIII, enantiomers of kynurenine, tryptophan, beta-blockers, practolol, thic ntal... 

Leyte, A., van Schijndel, H. B., Niehrs, C., Huttner, W. B., Verbeet, M. P., Mertens, K., et al. (1991). Sulfation ofTyrl680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with von WiUebrand factor. The Journal of Biological Chemistry, 266(2), 740-746. 

Enzymes as Coagulant Eactors as in Human Blood Coagulation Pathways... 

EFFECTS ON HUMAN BLOOD COAGULATION PATHWAY 19.3.1 Human Blood Coagulation Pathway... 

Blood coagulation Factors II and X, concentrate, human Blood coagulation Factor IXa concentrate, human, recombinant... 

Osterud, B., Bjorklid, E., Brown, S.F., 1979. The interaction of human blood coagulation factor Vn and tissue factor the effect of anti-factor VII, anti-tissue factor and diisopropylfluorophosphate. Biochem. Biophys. Res. Commun. 88 (1), 59-67. 

Retzios, A. D., and Markland, F. S. (1988). A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix Effects on various components of the human blood coagulation and fibrinolysis system. Thrombosis Res. 52 541... 

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