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Immobilization hollow-fiber bioreactor

Balcao, V.M., Malcata, F.X. 1998a. On the performance of a hollow-fiber bioreactor for acidolysis catalyzed by immobilized lipase. Biotechnol. Bioeng. 60, 114-123. [Pg.326]

Dual Hollow-Fiber Bioreactor for Aerobic Whole-Cell Immobilization... [Pg.32]

Before construction of the hollow-fiber bioreactor, the adhesion of bacterial cells to hollow fibers was studied in batch cultures. Cells were immobilized on 2-cm-long pieces of... [Pg.94]

Wee YJ, Yun JS, Kang KH, Ryu HW (2002) Continuous production of succinic acid by a fumarate-reducing bacterium immobilized in a hollow fiber bioreactor. Appl Biochem Biotechnol 98 1093-1104... [Pg.387]

Cell immobilized in an asymmetric hollow-fiber bioreactor (HFBR) with fumarate as carbon source Continuous biofilm fermentation with using plastic composite support bioreactors... [Pg.197]

An example of an industrial membrane bioreactor is the hollow-fiber membrane system for the production of (-)-MPGM (3-(4-methoxyphenyl)glycidic acid methyl ester), which is an important intermediate for the production of diltiazem hydrochloride [81, 82]. For the enantiospecific hydrolysis of MPGM a hollow-fiber ultrafiltration membrane with immobilized lipase from Serratia marcescens is used. (-f)-MPGM is selectively converted into (2S,3J )-(-F)-3-(4-methoxyphenyl)glyci-dic acid and methanol. The reactant is dissolved in toluene, whereas the hydrophilic product is removed via the aqueous phase at the permeate side of the membrane, see Fig. 13.9. EnantiomericaUy pure (-)-MPGM is obtained from the to-... [Pg.540]

Naruse et al. proposed another bioreactor design [22,23], in which porcine hepatocyte spheroids are immobilized on non-woven polyester fabric. This device allows more direct contact between hepatocytes and perfused medium and improves, therefore, the mass transfer capacity. The non-woven fabric module expressed better metabohc and synthetic functions at 24 hours than a hollow fiber module containing spheroids in suspension culture. Longer term results are not yet available and the immunoexclusion properties of this fabric have not been addressed. [Pg.104]

Immobilization of lipases on membranes have also been described and several bioreactors were developed (see review, Balcao, Paiva Malcata, 1996). The immobilization can be done by simple physical adsorption of the lipase on hydrophobic hollow fibers or flat sheets where polypropylene types are the preferred e.g. Accnrel or Celgard) (Bouwer, Cupenus Derksen, 1997). [Pg.256]

It is significant that the reaction mixture was worked up by removal of the unreacted ester by hexane extraction and concentration of the aqueous layer to obtain the desired (i )-amino acid. The process has a high throughput and was easy to handle on a large scale. However, because of the nature of a batch process, the enzyme catalyst could not be effectively recovered, adding significantly to the cost of the product. In the further scale up to 100-kg quantity productions, the resolution process was performed using Sepracor s membrane bioreactor module. The enzyme was immobilized by entrapment into the interlayer of the hollow-fiber membrane. Water and the substrate amino ester as a neat oil or hexane solution were circulated on each side of the membrane. The ester was hydrolyzed enantioselectively by the enzyme at the membrane interface, and the chiral acid product... [Pg.89]

Scheme 15. The proposed continuous production of polar head modified phospholipid (1), its purification by PA removal (2) and hydrolysis to the corresponding OP (3). The three enzymes are immobilized in hollow fiber hydrophobic membrane bioreactors [179]... Scheme 15. The proposed continuous production of polar head modified phospholipid (1), its purification by PA removal (2) and hydrolysis to the corresponding OP (3). The three enzymes are immobilized in hollow fiber hydrophobic membrane bioreactors [179]...

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See also in sourсe #XX -- [ Pg.33 ]




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