HIV receptor

Autoimmune deficiency disease Arylhydrocarbon hydroxylase receptor in humans and mice, respectively Acute promyelocytic leukemia All trans retinoic acid A member of the nuclear receptor family An inbred mouse strain An inbred mouse strain HIV receptor... 

Figure 33.39. HIV Receptor. A complex between a modified form of the envelope glycoprotein gpl20 from HIV and a...

Sattentau QJ, Weiss RA (1988) The CD4 andgen Physiological ligand and HIV receptor. Cell 52 631-633. 

Figure 33.42 HIV receptor. A complex between a modified form of the envelope glycoprotein gpl20 from HIV and a peptide corresponding to the two amino-terminal domains from the helper-T-cell protein CD4 reveals how viral infection of helper-T-cells is Initiated. [Drawn from IGCl.pdb.]...

Viruses may be constructed that express the HIV-receptor CD4 and coreceptor on the viral surface, either as part of the virus itself, or as the result of viral pseudotyping (55,56). These molecules then define the target-cell specificity of the virions, and they bind to and infect target cells expressing the HIV envelope on the cell surface (i.e., HIV-infected cells). If the virus itself is cytopathic, then it may kill the target cell (55). Alternatively, these viruses may be used to package nucleic acids for gene therapy, toxins, or other anti-HIV materials. 

Within 1-3 years after the discovery of human immunodeficiency virus (HIV) as the causative agent of acquired immune deficiency syndrome (AIDS) (1,2), the CD4 molecule was identified as the primary HIV receptor (3). HIV was shown to enter target cells by an initial binding event between the envelope glycoprotein (Env) molecules on the viral membrane and CD4 molecules on the target cell surface, followed by direct, pH-independent membrane fusion. Yet as early as 1986, it became clear that the Env-CD4 interaction was not sufficient to promote the fusion reaction (4-6) several lines of evidence indicated that the target cell must contain an additional human-specific cofactor (7-11), presumably a coreceptor. ... 

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