HIV infection and AIDS

Wood A, Armour D (2005) The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS, Prog Med Chem 43 239-271... 

Correia D, Rodrigues De Resende LA et al (2006) Power spectral analysis of heart rate variability in HIV-infected and AIDS patients. Pacing CUn Electrophysiol 29(l) 53-58 Craddock C, Pasvol G et al (1987) Cardiorespiratory arrest and autonomic neuropathy in AIDS. Lancet 2(8549) 16-18... 

Lohmoller G, Matuschke A et al (1989) [False-positive test of autonomic neuropathy in HIV infection and AIDS Case control study of heart rate variability in 62 HIV positive patients]. Med Klin (Munich) 84(5) 242-245... 

AIDSTRIALS (AIDS Clinical Trials). The AIDSTRIALS database [80] provides information about AIDS-related studies of experimental treatments conducted under the FDA s investigational new drug (IND) regulations. AIDSTRIALS contains information about clinical trials of agents undergoing evaluation for use against AIDS, HIV infection, and AIDS-related opportunistic diseases such as Pneumocystis carinii pneumonia (PCP). Detailed information is supplied... 

Suggested Alternatives for Differential Diagnosis Bronchitis, pneumonia, meningitis, gastroenteritis, septic shock, congestive heart failure and pulmonary edema, pleural effusion, costochondritis, prostatitis, adult respiratory distress syndrome (ARDS), HIV infection and AIDS, and Q fever. 

Donahoe, R.M. and Falek, A., Neuroimmunomodulation by opiates and other drugs of abuse relationship to HIV infection and AIDS, Adv. Biochem. Psychopharmacol., 44,145, 1988. 

Another consequence of methamphetamine addiction is increased risk for HIV infection and AIDS, since many meth users inject the drug intravenously and share needles. In fact, illegal drug use is one of the fastest-growing ways HIV is spread to other people. 

HIV PR inhibitors with acceptable oral availability and pharmacokinetic properties offer great promise for the treatment of HIV infection and AIDS. Efficacy studies of indinavir, ritonavir, or nelfinavir using plasma viral RNA as a marker have demonstrated up to three log reductions in RNA copy numbers that are... 

Considerable neuromuscular involvement also occurs in patients with AIDS.47 100 Peripheral neuropathies, myopathies, and various CNS manifestations (dementia, other psychological manifestations) can occur directly from HIV infection or secondarily, due to some other opportunistic infection.31 85 100 Likewise, peripheral neuropathies are a common side effect of certain anti-HIV drugs (didanosine, stavudine, zal-citabine), and myopathies are a side effect of zidovudine therapy.63 Patients with HIV disease often have painful symptoms such as joint pain, back pain, and pain related to neuropathies and myopathies.100 Hence, HIV disease can often be regarded as a degenerative neuromuscular disorder from the standpoint of a rehabilitation professional. Therapists can therefore help improve function and decrease pain in patients with HIV infection and AIDS.1 33... 

In addition, viral infections may produce pain and other symptoms that can be treated by physical rehabilitation. In particular, chronic HIV infection and the drug therapy for this disorder can both produce neuromuscular problems such as myopathy and peripheral neuropathy.63,83 Neuromuscular impairments can occur at any stage in the disease process, but they become especially problematic in advanced cases of HIV infection, or when this disease progresses to AIDS.7,63 Hence, therapists can use various physical agents to help decrease pain, and likewise implement aerobic and resistive exercise programs to help maintain muscle strength and function.68 These interventions can be invaluable in helping maintain quality-of-life in people with HIV infection and AIDS. 

Tehranzadeh J, Ter-Oganesyan RR, Steinbach LS. Musculoskeletal disorders associated with HIV infection and AIDS. Part II non-infectious musculoskeletal conditions. Skeletal Radiol. 2004 33 311-320. 

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