History Data

Like concomitant medication data, patient medical history data are collected in one of two forms a list-type free-text format where the histories get coded, or a pre-categorized data format. Here is the free-text CRF format  

Protocol Name Patient Number - Visit Identifier 

the free-text CRF format is useful in that it allows for explicit description of the historical condition, whereas the pre-categorized CRF format omits that detail. However, the free-text list format necessitates coding with a coding dictionary such as MedDRA in order to be useful for analyses. The pre-categorized format is useful here, as only medical history relevant to the investigational therapy can be captured and the cost of additional coding of the history data is eliminated entirely. 

Medical history data may be used in either safety or efficacy analyses. The presence of historical medical conditions may be used as covariates for inferential analyses. Also, medical histories are typically summarized to show that the therapies under study come from study populations with comparable disease histories. Medical histories may be used to determine protocol compliance and to help define a protocol-compliant study population. Medical history is considered a finding from a CDISC perspective. 

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Relevance to publie or eoologieal health Sensitivity to ehanges in mereuiy loading Availability of historieal data Part of an existing data eolleetion infrastrueture... 

Demographics and Trial-Specific Baseline Data 27 Concomitant or Prior Medication Data 27 Medical History Data 29 Investigational Therapy Drug Log 30 Laboratory Data 31 Adverse Event Data 32 Endpoint/Event Assessment Data 35 Clinical Endpoint Committee (CEC) Data 36 Study Termination Data 37 Treatment Randomization Data 38 Quality-of-Life Data 40... 

Note that by changing the aesev variable to the aerel variable throughout Program 5.4, you can easily change the previous adverse event summary to a summary of adverse events by maximum drug relatedness. Also, if you remove the maximum severity steps, you get a typical overall summary of adverse events by body system and preferred term. Since patient medical history data are also often coded with MedDRA, patient medical history data may be summarized much like an overall summary of adverse events. However, frequently medical histories are collected in a checklist/checkbox format so that using a coding dictionary is unnecessary. 

Fig. 1 World marketed energy consumption, 1970-2025. Reference History data from Energy Information Administration (EIA), International energy annual, 2002, DOE/EIA-0219 (2002), Washington, DC, March 2004. Projection data from EIA, System for the analysis of global energy markets, 2005.

RMP Info (Five-Year Accident History Data) EPA Retrieved information... 

Figure 9-1 gives production pressure history data for a typical black oil reservoir. The reservoir in this case does not have a gas cap and is not connected to an aquifer. The conventional method of plotting these data is against time. However, the trends we want to see are more apparent when the data are plotted against cumulative production, as in Figure 9-2. 

It has been shown how various factors can affect the appearance of XRD patterns and how the subtle differences in those patterns can be used to gain valuable structural and characterization information. It is clear that in order to understand a material and define it properly, all of these factors must be examined carefully. Techniques in addition to XRD, particularly electron microscopy, but also sorption and spectroscopy, should be utilized when attempting to understand the nature of a new catalyst material. Finally, it must be recognized that published XRD powder data for a given material can tell much about its structural nature but, to interpret the XRD data properly, it is also necessary to be aware of sample history, data collection parameters, morphology, etc. In short, one must know as much as possible about the various factors that affect the x-ray diffraction characteristics of catalyst materials. 

Barnthouse, L.W., G.W. Suter, II, and A.E. Rosen. 1990. Risks of toxic contaminants to exploited fish populations Influence of life history, data uncertainty, and exploitation intensity. Environ. Toxicol. Chem. 9 297-311. 

Another important contributor of uncertainty is the incompleteness of the data or information upon which the risk assessment is based. In some instances, the risk assessment may be halted temporarily until additional information is obtained. In other cases, certain basic information such as life history data may be unobtainable with the resources available to the risk assessment. In yet other cases, fundamental understanding of some natural... 

Several levels of feedback of dosing history data to patients probably have future roles. A basic maneuver can be audible or visual status alerts for... 

Many patients rely on a caregiver or family member to assist them with their medications. These individuals can be a valuable source for patient drug history data. ... 

Intake of process flavors from foods in various categories was determined based on the Nationwide Food Consumption Survey (NFCS) database, which was derived from surveys of U.S. food consumption conducted by the U.S. Department of Agriculture (USDA) in 1977-1978. Although 1987-1988 data were available, the 1977-1978 data were considered to be more representative of the general population (n= 30,770 n = 28,006 for individuals providing a 3-day diet history) than the more recent 1987-1988 data (n = 10,193 total n = 8,224 with a three-day diet history). Data were not available for the years after 1988 at the time the analyses reported here were performed. 

Pilch M, Erdman C. Use of breakup time data and velocity history data to predict the maximum size of stable fragments for acceleration-induced break-up of a liquid drop. Int J Multiphase Flow 1987 13 741-757. 

Figure 6.14 U.S. sulfuric acid and ammonia production histories. (Data cour-...

Figure 6.15 U.S. chlorine production history. (Data courtesy of CMAI.)...

Figure 6.24 United States cumene/phenol production histories. (Data courtesy of CMAl.)...

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