Calcium and histamine secretion from mast cells

Calcium and histamine secretion from mast cells, 19 (1982) 59... 

Mast cells, calcium and histamine secretion from, 19(1982)59... 

Church, M. K., Pao, G. J. K., and Holgate, S. T., 1982, Characterization of histamine secretion from mechanically dispersed human lung mast cells Effects of anti-IgE, calcium ionophore A23187, compound 48/80, and basic polypeptides, J. Immunol. 129 2116-2121. 

NT was initially reported to stimulate the non-cytotoxic release of histamine from isolated rat peritoneal mast cells by workers in our laboratory [40, 79]. This observation has now been confirmed and extended by several other workers [80-85]. When added to isolated rat serosal mast cells, NT initiates the secretion of histamine which is dependent upon calcium and energy [79]. Secretion begins at about 10 nanomolar NT and reaches an initial plateau of some 20% histamine release at 10 piM NT [79] (Figure 4.2) while higher levels... 

As the injection of CaCh (0.1 M) into individual rat peritoneal mast cells elicited secretory granule extrusion (Kanno et al. 1973), calcium might be involved in some stage of the secretion process (Goth 1978). M-benzhydryl-hT-p-hydroxybenzyl-piperazine, a potent anti-histaminic and anti-sero-toninergic calcium blocker, prevented mast cells from degranulation (Fig. 195), while the introduction of particulate matter into the body induced mast cell degranulation (Fig. 196). 

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