Heart mast cell

M, Marone G Human heart mast cells. Isolation, purification, ultrastructure and immunologic characterization. J Immunol 1995 154 2855. 28... 

G, Adenylyl cyclase-catalyzed cAMP production Brain, stomach, smooth muscle, heart, mast cells Arpromidine, impro-midine, amthamine, dimaprit Cimetidine, ranitidine, famotidine... 

Protein Fv Is an Endogenous Superallergen That Activates Human Heart Mast Cells... 

Mast cells are found in the human heart [31, 52], around coronary arteries [53], and in the coronary intima [54], Human heart mast cells have been implicated in the pathophysiology of myocarditis [55, 56], coronary artery diseases [53] and dilated cardiomyopathy [57], Finally, mast cells, through the release of vasoactive mediators, are also involved in systemic vasculitis [39],... 

Fig. 5. Correlations between the maximum percent of histamine secretion and PGD2 and LTC4 release induced by protein Fv from human heart mast cells. Each point is the mean of duplicate determinations from separate experiments. (Reproduced with permission from Genovese et al. [58].)... 

Our results provided the first evidence that an endogenous superantigen, protein Fv, released during viral infections, can induce the in vitro synthesis and secretion of several important mediators from human heart mast cells. The activity of protein Fv is extremely potent, raising the possibility that it exerts important effects in vivo. Although as yet there are no data about serum concentrations of protein Fv in different pathophysiological conditions, it is not inconceivable that this protein synthesized by the liver in patients with acute and chronic HCV, HAY or HBV infection contributes, through the release of... 

Patella V, de Crescenzo G, Marino I, Genovese A, Adt M, Gleich GJ, Marone G Eosinophil granule proteins activate human heart mast cells. J Immunol 1996 157 1219-1225. 

Genovese A, Bouvet JP, Florio G, Lamparter-Schummert B, Bjorck L, Marone G Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E. Infect Immun 2000 68 5517-5524. 

H, Stomach, heart, mast cells G3 TcAMP Cimetidine... 

The rote of the heart in anaphylaxis, in particular, the heart mast cells in cardiovascular collapse. 

M to3x10 Min vitro with human basophils, skin, lung, and heart mast cells t SteUato et al. Anesthesiology. 1992 77 932 Marone et al. Ann Fr Anesth Reanim. 1993 12 116... 

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