Mast cells, calcium and histamine secretion

Mass spectrometry and glc, 12 (1975) 1 Mast cells, calcium and histamine secretion, 19 (1982) 59... 

Calcium and histamine secretion from mast cells, 19(1982)59... 

NT was initially reported to stimulate the non-cytotoxic release of histamine from isolated rat peritoneal mast cells by workers in our laboratory [40, 79]. This observation has now been confirmed and extended by several other workers [80-85]. When added to isolated rat serosal mast cells, NT initiates the secretion of histamine which is dependent upon calcium and energy [79]. Secretion begins at about 10 nanomolar NT and reaches an initial plateau of some 20% histamine release at 10 piM NT [79] (Figure 4.2) while higher levels... 

The stomach secretes hydrochloric acid under the influences of vagus nerve stimulation, gastrin and histamine. Histamine is the most potent stimulus of gastric acid secretion in some animal species studied, such as the horse (Kitchen et al 1998a). Histamine is released by mast cells and enterochromaffin-like cells that are immediately adjacent to the parietal cells. Histamine interacts with two distinct subsets of histamine H2 receptors on the parietal cell membrane, initiating a series of reactions that result in the phosphorylation of protein kinases and increased intracellular calcium within the parietal cell. This, in turn, results in transformation and translocation of the... 

As the injection of CaCh (0.1 M) into individual rat peritoneal mast cells elicited secretory granule extrusion (Kanno et al. 1973), calcium might be involved in some stage of the secretion process (Goth 1978). M-benzhydryl-hT-p-hydroxybenzyl-piperazine, a potent anti-histaminic and anti-sero-toninergic calcium blocker, prevented mast cells from degranulation (Fig. 195), while the introduction of particulate matter into the body induced mast cell degranulation (Fig. 196). 

Church, M. K., Pao, G. J. K., and Holgate, S. T., 1982, Characterization of histamine secretion from mechanically dispersed human lung mast cells Effects of anti-IgE, calcium ionophore A23187, compound 48/80, and basic polypeptides, J. Immunol. 129 2116-2121. 

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