Histamine inhibition

Schlicker, E., Fink, K., Detzner, M. Gothert, M. (1993). Histamine inhibits... 

Histamine inhibits neutrophil chemotaxis due to HR2 triggering, which is mimicked by impromidine (HR2 agonist), but not by betahistine (HRl agonist). In addition, histamine inhibits neutrophil activation, superoxide formation and degranulation via HR2 [40]. Downregulation of... 

In monocytes stimulated with Toll-like receptor-triggering bacterial products, histamine inhibits the production of proinflammatory IL-1-like activity, TNF-a, IL-12 and IL-18, but enhances IL-10 secretion, through HR2 stimulation [26, 69]. Histamine also downregulates CD 14 expression via Hj receptors on human monocytes [70]. The inhibitory effect of histamine via Hj receptor appears through the regulation of ICAM-1 and B7.1 expression, leading to the reduction of innate immune response stimulated by LPS [71]. 

Van der Pouw Kraan TC, Snijders A, Boeije LG, de Groot ER, Alewijnse AE, Leurs R, Aarden LA Histamine inhibits the production of interleukin-12 through interaction with Hj receptors. J Clin Invest 1998 102 1866-1873. 

Morichika T, Takahashi HK, Iwagaki H, Yoshino T, Tamura R, Yokoyama M, et al Histamine inhibits lipopolysac-charide-induced tumor necrosis factor-01 production in an intercellular adhesion molecule-1- and B7.1-depen-dent manner. J Pharmacol Exp Ther 2003 304 624-633. 

Endogenous histamine has a modulating role in a variety of inflammatory and immune responses. Upon injury to a tissue, released histamine causes local vasodilation and leakage of plasma-containing mediators of acute inflammation (complement, C-reactive protein) and antibodies. Histamine has an active chemotactic attraction for inflammatory cells (neutrophils, eosinophils, basophils, monocytes, and lymphocytes). Histamine inhibits the release of lysosome contents and several T- and B-lymphocyte functions. Most of these actions are mediated by H2 or H4 receptors. Release of peptides from nerves in response to inflammation is also probably modulated by histamine, in this case acting through presynaptic H3 receptors. 

Schlicker E, Fink K, Detzner M, Gothert M (1993) Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors. J Neural Transm [Gen Sect] 93 1-10. 

Bissonnette, E.Y., 1996. Histamine inhibits tumor necrosis factor a release by mast cells through H2 and H3 receptors. Am. J. Respir. Cell. Mol. Biol. 14, 620-626. 

Schworer, H., Katsoulis, S., Racke, K., 1992. Histamine inhibits 5-hydroxytryptamine release from the porcine small intestine involvement of H3 receptors. Gastroenterology 102, 1906-1912. 

Schlicker E, Fink K, Detzner M, Gothert M (1993) Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors. J Neural Transm Gen Sect 93 1-10 Schlicker E, Kathmann M, Detzner M, Exner HJ, Gothert M (1994) H3 receptor-mediated inhibition of noradrenaline release an investigation into the involvement of Ca2+ and K+ ions, G protein and adenylate cyclase. Naunyn Schmiedeberg s Arch Pharmacol 350 34 11 Schlicker E, Werthwein S, Zentner J (1999) Histamine H3 receptor-mediated inhibition of noradrenaline release in the human brain. Fundam Clin Pharmacol 13 120-2 Schmitz D, Gloveli T, Empson RM, Draguhn A, Heinemann U (1998) Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanism. J Physiol 508 119-29... 

According to Sue (SIO), blood poisoning during pregnancy placed a stress on the supply of pyridoxine by reason of excess protein metabolism. This fact, together with the presence of elevated amounts of histidine and histamine, inhibited the action of vitamin Bb, and caused excretion of large quantities of xanthurenic acid. 

Busse, W. W., and Sosman, J., 1976, Histamine inhibition of neutrophil lysosomal enzyme release An H2 histamine receptor response. Science 194 737-738. 

Dohlsten, M., Sjogren, H. O., and Carlsson, R., 1986, Histamine inhibits interferon-y production via suppression of interleukin 2 synthesis. Cell Immunol. 101 493-501. 

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