Histamine cromolyn sodium inhibition

Anaphylactic Inhibitors - Cromolyn sodium Inhibits the release of allergic mediators such as histamine and SRS-A from sensitized tissues, but does not interfere with the combination of antigen and antibody. Like its precursor azatadine, azanator maleate (Sch 15,280) has significant antimediator... 

Cromolyn sodium (sodium cromoglycate) inhibits exocytosis of mast cells, thus blocking the release of histamine and leukotrienes. It is used mainly to prevent attacks (e.g. those triggered by exercise). 

Even though various antileukotriene drugs have been synthesized, none has reached clinical acceptability. Inhibition of histamine release by an apparent mast cell stabilizing mechanism (in lung tissue, but probably not elsewhere) is achieved with the carboxy-chromone derivative cromolyn sodium. The mechanism is believed to involve inhibition of histamine release from pulmonary mast cells by blocking Ca2+ movement through membrane channels. 

Cromolyn Sodium (Nasalcrom) Inhibits release of histamine from mast cells. Prophylaxis of bronchial asthma seasonal allergic conjunctivitis. Well tolerated. Local irritation, headache, unpleasant taste. 

Cromolyn sodium is administered by inhalation. Its mode of action involves the inhibition of the release of histamine and other inflammatory mediators from several cell types. Its main use is for the prophylactic treatment of bronchial asthma. Inhalation of a selective [beta-2]-adrenergic agonist such as albuterol is the preferred form of bronchodilator therapy for asthma. 

---