Hippocratea excelsa

Mean-Rejon, G. J. Perez-Espadas, A. R. Moo-Puc, R.E. Cedillo-Rivera, R. Bazzocchi, I. L. Jimenez-Diaz, I. A. Quijano, L. Antigiardial activity of triterpenoids from root bark of Hippocratea excelsa. J. Nat. Prod. 2007, 70, 863-865. 

The first Mexican substance searched for, found, and isolated based on old traditions, was the sesquiterpene hemandulcin from Lippia dulcis Trev. It was determined by a human taste panel to be more than 1000 times sweeter than sucrose. The structure of this sesquiterpene was determined and confirmed by chemical synthesis. It was nontoxic when administered orally to mice, and did not induce bacterial mutation.5 Further work has been carried out with some of the plants more frequently used (Table 12.3). The sesquiterpene alkaloids hippocrateine I, hippocrateine II, and emarginatine were identified in Hippocratea excelsa used in Mexican traditional medicine, and antimicrobial abietane type diterpenes were isolated from Salvia albocaerulea.6 7... 

MATA, R., CALZADA, F., DIAZ, E., TOSCANO, R.A., Chemical studies on Mexican plants used in traditional medicine. XV. Sesquiterpene evoninoate alkaloids from Hippocratea excelsa, J. Nat. Prod., 1990,53,1212-1219. 

Hippocrateine I and II (52a,b) were first isolated from root and stem barks of Hippocratea excelsa[ 180], Structures of these compounds were established using FABMS, CIMS, and one-and two-dimensional 1H and NMR. The structure of 52a was confirmed by X-ray crystallography, and its absolute configuration determined by comparison with the known absolute stereochemistry of acanthothamine. Hippocrateine I (52a) was found to be slightly active in the brine shrimp lethality assay (LC50 = 212 pg/ml) and in the 9PS cytotoxicity assay (ED50 = 1.85 x 10"1 pg/ml), but it was inactive in the A-549, HT-29 and MCF-7 cell culture assays [180],... 

The reddish brown bark, commonly known as cancerina of Hippocratea excelsa H.B.K., is valuable for treating skin ailments and gastric ulcers and for its pesticidal properties. The sesquiterpene evoninoate alkaloids hippocrateine I (58) and II (59), Fig. (18), were... 

Fig. (18). Macrocyclic sesqiterpenes alkaloids from Hippocratea excelsa...

Furukawa M, Makino M, Uchiyama T, Ishimi K, Ichinone Y, Fujimoto Y. Sesquiterpene pyridine alkaloids from Hippocratea excelsa. Phytochemistry 2002 59 (7) 767-77. 

A series of sesquiterpene evoninoate alkaloids have been isolated from the liana Hippocratea excelsa (Hippocrateaceae) from Mexico (Mata, 1993 Mata et al., 1990). This plant, called cancerina, is used medicinally to treat skin ailments and for its pesticidal properties. The main alkaloid, hippocrateine I (21), was cytotoxic in the 9 PS system (ED50 1.85 X 10 xg/ml) (Mata et al., 1990). This plant also contains small amounts of the antitumor triterpene tingenone (see Chapter 23). 

Mata, R., F. Calzada, E. Diaz, and R. A. Toscano, Sesquiterpene evoninoate alkaloids from Hippocratea excelsa, Planta Medica, 56, 517 (1990). 

Alkaloid from root and stem barks of Hippocratea excelsa (Celastraceae). Gum. Note differing regiochemistry of nicotinoyl group compared with Hippocrateine I, H-00897. 

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