High with mass spectrometric detection

G. S. Frysinger and R. B. Gaines, Comprehensive two-dimensional gas chromatogr aphy with mass spectrometric detection, (GC X GC/MS) applied to the analysis of petr oleum , /. High Resolut. Chromatogr. 22 251 -255 (1999). 

Ayrton J. et al., 1998. Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct online analysis of pharmaceuticals in plasma. J Chromatogr A 8282 199. 

If reaction (2-13) follows reaction (2-12) instantaneously, the effect will not be noticeable in the H2 signal [12]. In spite of these limitations, we conclude that TPS with mass spectrometric detection is a highly useful technique for studying the sulfidation of hydrotreating catalysts. We shall return to the sulfidation of molybdenum oxides in the chapters on photoemission (Chapter 3), ion spectroscopy (Chapter 4), and in a case study on hydrodesulfurization catalysts in Chapter 9. 

McCooeye, M. A., Ells, B., Barnett, D. A., Purves, R. W., and Guevremont, R. (2001). Quantitation of morphine and codeine in human urine using high-field asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection. J. Anal. Toxicol. 25 81-87. 

Woo JS (2006) Nasal absorption studies of granisetron in rats using a validated high-performance liquid chromatographic method with mass spectrometric detection. Arch Pharm Res 30 778-784... 

The preponderance of analytical (and preparative) separations that precede mass spectrometric analyses are carried out using HPLC. Despite its potential for extremely high efficiencies, capillary electrophoresis (CE) remains something of a specialized application, particularly with mass spectrometric detection. The technique is hampered by its reliance on small sample volumes (typically nL injections) in order to avoid loss of separation efficiency. The consequence of these small volumes is a concentration detection limit that is substantially higher than that of techniques such as HPLC. Despite the exquisite sensitivity of mass spectrometers, characterization of related substances present at low femtomole levels (assuming a hypothetical related substance compound with molecular weight 500 daltons present at 0.1% w/w in an equally hypothetical drug substance sample... 

If the ionic strength and pH of the perfusate do not match those of the extracellular environment the physiological conditions will be perturbed. Results from experiments performed under these conditions could then be a product of factors that are not accounted for experimentally. While this can be less important in a blood vessel than in the brain, where all processes are affected by electrolyte levels, the perfusate composition is very important in the reliability of the results. Analysis of microdialysis samples with mass spectrometric detection offers a special challenge because the high salt concentration of the dialysate could affect the sensitivity of the spectrometer. 

One of the early methods for mass spectrometric analysis of microdialysis samples utilized gas chromatography with mass spectrometric detection (GC/MS). Electron ionization is one type of ionization used for GC/MS. It is a hard ionization technique, resulting in a high degree of analyte fragmentation. A softer form of ionization, chemical ionization, is also available and often results in less analyte fragmentation. Selected-ion monitoring (SIM) is used frequently with... 

Bayliss, M.K. Little, D. Mallett, D.N. Plumb W.S. Parallel Ultra-high Plow Rate Liquid Chromatography with Mass Spectrometric Detection Using a Multiplex Electrospray Source for Direct, Sensitive Determination of Pharmaceuticals in Plasma at Extremely High Throughput, Rapid Commun. Mass Spectrom. 14, 2039-2045 (2000). 

It was required that the final determination should be carried out by capillary gas chromatography with high resolution mass spectrometric detection and that two isotope... 

The PCDD and PCDF were determined by high-resolution capillary gas chromatography with mass spectrometric detection. Each isomer was identified and confirmed, using at least two columns with different stationary phases and polarity, by comparing the relative retention times of the peaks in the calibration and sample chromatograms. The final quantification was made using relative peak height or peak area. The GC and MS conditions used by each laboratory are summarised elsewhere [18,19]. 

PL 95-3327 SMT4-CT96-2142 Determination of priority herbicides, insecticides, and fungicides by high performance liquid chromatography with mass spectrometric detection after solid-liquid extraction. 

Berset, J. D. and Etter-Holzer, R., Determination of phthalates in crude extracts of sewage sludges by high-resolution capillary gas chromatography with mass spectrometric detection, J. AOAC Int., 84, 383-391, 2001. 

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