Targets high-value

Kijanolide 117,76 tetronolide 118,76 and chlorothricolide 119,77 the agly-cones of the structurally novel antitumor antibiotics kijimicin, tetrocaricin A, and chlorothrimicin, are highly valued targets for total synthesis. All three structures share a similar octahydronaphthalene fragment 121, which can be obtained by cyclization of 120. Compound 120, appropriately functionalized 2,8,10,12-tetradecatetraene acid, can be constructed via aldol reactions. Two... 

Military Advantage and the Value of Targets 13.3.1 High-Value Targets... 

Hull E (2011) High-value target countering A1 Qaeda in Yemen. Potomac Books, Washington DC... 

Reliability prediction - a technique for establishing product characteristics where the reliability targets cannot be measured without testing many hundreds of products over many thousands of hours. (On long production runs of low value items, reliability testing is possible but with one-off systems of high value it is not cost effective hence reliability has to be predicted using statistical techniques.)... 

Given that, under the defined conditions, there is no interfacial kinetic barrier to transfer from phase 2 to phase 1, the concentrations immediately adjacent to each side of the interface may be considered to be in dynamic equilibrium throughout the course of a chronoamperometric measurement. For high values of Kg the target species in phase 2 is in considerable excess, so that the concentration in phase 1 at the target interface is maintained at a value close to the initial bulk value, with minimal depletion of Red in phase 2. Under these conditions, the response of the tip (Fig. 11, case (a)] is in agreement with that predicted for other SECM diffusion-controlled processes with no interfacial kinetic barrier, such as induced dissolution [12,14—16] and positive feedback [42,43]. A feature of this response is that the current rapidly attains a steady state, the value of which increases... 

Although, these capabilities can be directed to multiple products to target different markets (chemicals, agriculture, protein pharmaceuticals, and prophylactic and therapeutic vaccines) their activities are currently focused to the Health Sector. Within these markets, they are focused on specific high-value opportunities. 

Capacitance of this type of material reaches extremely high values over 300 F/g. Our target is to correlate it with the total specific surface area, pore size distribution, particle size and elemental composition of carbon. 

However, while it is clear that biocatalysts may only provide viable and reliable methods in about 5-10% of all transformations of interest to synthetic organic chemists, it is also clear that in some cases the biotransformation will provide the key step in the best method in going from a cheap substrate to a high value, optically active fine chemical. Thus ignoring biotransformations altogether means one may occasionally overlook the best pathway to a target structure. 

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