High-value soft targets

Nowadays, partly initiated by the advent of ESI as a powerftrl soft ionization technique for highly polar biomolecules and as a convenient method to couple LC and MS, MS-MS is frequently applied. For routine quantitative bioanalysis of target compounds, the selected reaction monitoring (SRM) mode is extensively applied. In the SRM mode, both stages of mass analysis perform the selection of ions with a particular m/z value, i.e., in MSI a precm ior ion, mostly the protonated or... 

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