1.6- Hexane diisocyanate

The Poly methane Polymer of 2,5-Dinitraza-1,6-Hexane Diisocyanate and 2,2-Din it ro-1,3-Propanediol. 

A polyurethane was synthesised from 1,6-hexane diisocyanate, polycaprolactone diol and a fluoroquinolone antibiotic, ciprofloxacin and characterised by size exclusion chromatography and elemental analysis. The PU was incubated in a solution of an inflanunatoiy cell-derived enzyme, cholesterol esterase or phosphate buffer for 30 days at 37C and its biodegradability determined by HPLC, mass spectroscopy and Carbon 14 radiolabel release. Analysis of the solution revealed that ciprofloxacin was released and able to inhibit the growth of Pseudomonas aeruginosa. 53 refs. 

An example of polyaddition-type step-growth polymerization is the preparation of polyurethane by the ionic addition of diol (1,4 butanediol) to a diisocyanate (1,6 hexane diisocyanate) (Equation 2.29). 

The crosslinking temperature of aliphatic poly(isocyanate)s, based on 1,6-hexane diisocyanate, which are blocked with equimolar quantities of diisopropylamine and 1,2,4-triazole is 139°C, without the addition of any catalyst. Aliphatic poly(isocyanate)s, which are bloeked with equimolar quantities of diisopropylamine and malonic acid diethyl ester have a cross-linking temperature of 130°C. °... 

A diamine curing agent for polyurethanes introduced in 1976 to replace the popular but toxic MOCA . It is very soluble in a variety of coating solvents. 2,2,4-Trimethyl-l,6-hexane diisocyanate... 

Hexane"bis"Semicarbazide, 20. 1,6-Hexane diisocyanate, J7, was obtained from Eastman Chemical Co. and was used without further purification. 

To a 500 ml three-necked, round-bottomed flask equipped with a water-cooled condenser attached to a drying tube containing silica gel, a mechanical stirrer, an addition funnel, and a thermometer was added 46.5 g (0.476 mole) of ethyl carbazate and 200 ml of dry benzene. The solution was stirred and cooled in an ice bath at approximately lO C. A solution of 40 03 g (0.238 mole) of 1,6-hexane diisocyanate, jJ, in 10 ml of benzene was added dropwise over a period of 40 minutes. The temperature was kept at approximately 20-30 C. After 2 minutes, a white solid began to form, and a thick solid was obtained by the end of the addition. The voluminous white slurry was stirred at room temperature for 45 minutes, then was refluxed for 2 hours. The mixture was cooled, and the white solid was filtered using suction filtration, then dried overnight in a vacuum oven at 50 C to yield 88.94 g (99.3%) of white solid m.p. 202-203 C. ... 

Subsequently, Bayer and coworkers, obtained hexane diisocyanate from the reaction of 1,6-hexamethylenediamine hydrochloride and phosgene. Tliis product was reacted with butane diol to produce several kilograms of aliphatic polyurethane. The melting point of this polymer U84 C) was too low for textile fiber applications, but it is still used for the production of bristles. 

Azo-cleavage by colonic bacteria inspired the synthesis of amino salicylic acid-based PU system (Figure 8.17). The amino salicylate was diazotized and then self-coupled the free phenolic groups were then utilized to synthesize PUs with hexane diisocyanate [107]. 

TGFb, Tissue Growth Factor Beta ACL, Anterior Cruciate Ligament MCL, Medial Collateral Ligament PP, Polypropylene , Ethylene Oxide HDI, Hexane Diisocyanate PMMA> Poly(methyl methacrylate) EGF> Epidermal Growth Factor. 

Novel polyurethanes were prepared by solvent polycondensation reaction of 1,6-hexane -diisocyanate with 4-[(4-hydroxy-2-pentadecenylphenyl)azo]phenol, synthesized from cardanol, and 1,4-butanediol [281]. A novel terpolyester was synthesized by solvent polycondensation of tere-phthaloyl chloride with 4-[(4-hydroxy-2-pentadecenyl phenyl) diazenyl]phenol (synthesized from cardanol) with 1,4-butanediol [282]. 

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