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Heterocyclic compounds, sulfur-containing, preparation

In comparison with other 1,3-dipoles that have been extensively explored in organic synthesis (7), sulfur-centered 1,3-dipoles (1-4) are rather uncommon species. However, within the last two decades, remarkable progress has been made regarding both methods of generation and synthetic applications. In particular, thiocarbonyl ylides (1) were established as key intermediates useful for the preparation of sulfur-containing heterocyclic compounds. General methods for the preparation of thiocarbonyl ylides and their chemical reactivity have been reviewed (8-11). [Pg.316]

The following types of dipolarophiles have been used successfully to synthesize five-membered heterocycles containing three heteroatoms by [3 + 2]-cycloaddition of thiocarbonyl ylides azo compounds, nitroso compounds, sulfur dioxide, and Al-sulfiny-lamines. As was reported by Huisgen and co-workers (91), azodicarboxylates were noted to be superior dipolarophiles in reactions with thiocarbonyl ylides. Differently substituted l,3,4-thiadiazolidine-3,4-dicarboxylates of type 132 have been prepared using aromatic and aliphatic thioketone (5)-methylides (172). Bicyclic products (133) were also obtained using A-phenyl l,2,4-triazoline-3,5-dione (173,174). [Pg.344]

Saturated three- and four-membered heterocyclics absorb little in the readily accessible regions of the UV spectrum. Sulfur-containing rings are an exception, as can be seen in Table 9, Despite the lack of absorption of most parent compounds, there is a wealth of photochemistry of small heterocyclics. Light absorption by substituents, and energy transfer from photoexcited molecules present in the photoreactive system make photoconversion of the heterocycles practical. On the other hand, the lack of substantial absorption of their own can be exploited in the preparation of small heterocycles, by designing the system to be unsuitable for destructive energy transfer. [Pg.153]

Sulfur dyes are a special class of dyes with regard to both preparation and application, and knowledge of their chemical constitution [1], They are made by heating aromatic or heterocyclic compounds with sulfur or species that release sulfur. Sulfur dyes are classified by method of preparation as sulfur bake, polysulfide bake, and polysulfide melt dyes. Sulfur dyes are not well-defined chemical compounds but mixtures of structurally similar compounds, most of which contain various amounts of both heterocyclic and thiophenolic sulfur. [Pg.78]

On the use of carbon disulfide for synthesizing sulfur-containing heterocyclic compounds see Mayer and Gewald.62 Compounds of type 8 prepared by the procedure described above are listed in Table VI. [Pg.242]

The application of ionic hydrogenation to sulfur-containing heterocycles is of special significance as heterogeneous catalysts are usually poisoned by sulfur compounds. This fact makes tetrahydrothiophenes, in particular, rather difficult to prepare. Thus, ionic hydrogenation is an extremely powerful and efficient method for the preparation of this class of compounds21,24, as illustrated in the synthesis of biotin derivatives 225. [Pg.1015]

All the P-As and P=As bonded compounds are sensitive to hydrolysis and to oxidation by air. The reaction of Cp As=PMes with diazomethane adds a CH2 group across the double bond and yields the three-membered heterocyclic phosphaarsirane Cp AsCH2PMes. Sulfur and selenium add across the double bond to form three-membered heterocycles.Dimerization of Cp As=PCp produces two isomeric diphosphadiarsetanes, one containing the P-P-As-As and the other the P-As-P-As core. Photolysis of Cp As=PMes, Cp P=AsMes, and (2,4,6-r-Bu3C6H2)P=AsCp yields the diarsadiphosphacyclo-butanes. Metal complexes of several of the P=As compounds have been prepared and characterized. ... [Pg.261]

It should be pointed out that synthesis of perfluorinated sulfur(II)-containing heterocycles, requires a custom synthetic approach, since of these compounds cannot be prepared using oxidative methods, such as electrochemical fluorination or fluorination using elemental fluorine, due to ability of divalent sulfur to undergo oxidation. [Pg.383]

There are those happy users who dissolve their sample in the mobile phase and inject right away. If you are one of these and you also have isocratic conditions with acetonitrile/water, you can forget about sample preparation for now. There are however those users who need to quantify minor unknown impurities of a metabolized metabolite from bile fluid and others who hunt after heterocyclic sulfur-containing compounds in crude oil residue from Iran and compare it with Iraqi oil. They all have my sympathy. In the following table, a few typical errors occurring in a normal sample preparation are listed. [Pg.61]

Study of the crystal structure of sulfur-containing heterocyclic compound 292, prepared by the reaction of diethyl dihydroxythieno[2,3-Z)]thiophene-2,5-dicarbox-ylate with Lawesson s reagent in the presence of sulfur, revealed the presence of a three-dimensional S-S interaction (93ZN1621). [Pg.171]

In 2005, J0rgensen et al. extended the conjugate addition of sulfur nucleophiles to a,P-unsaturated aldehydes under iminium catalysis with trimethylsilyl ether 56 (10 mol%) as catalyst [385]. Very high enantioselectivities (89-97% ee) were reported for the addition of aliphatic thiols to different aromatic and aliphatic enals at low temperatures (-24°C) where the employment of an acid cocatalyst (PhCOjH, 10 mol%) was mandatory in order to improve the reaction rate. This methodology has been incorporated into domino reactions by the same group and others to successfully prepare optically active sulfur-containing heterocyclic compounds [385, 386],... [Pg.171]

A large number of heterocyclic compounds of oxygen, nitrogen, and sulfur are prepared by condensation of di- or poly-functional compounds. Nitrogen-containing heterocycles by the thousands have been prepared by such reactions. The simplest such reaction is one leading to the preparation of a pyrrolidine or piperidine derivative. The synthesis of pyrrolidine may be accomplished by reaction of ammonia and 1,4-dichlorobutane in a stepwise process that may include an intramolecular displacement of chloride from the aminoalkyl chloride [Eq. (31)] or of ammonia from the aminoalkyl amine hydrochloride" [Eq. (32)] each process is known to occur. [Pg.249]


See other pages where Heterocyclic compounds, sulfur-containing, preparation is mentioned: [Pg.12]    [Pg.152]    [Pg.33]    [Pg.60]    [Pg.184]    [Pg.361]    [Pg.153]    [Pg.12]    [Pg.12]    [Pg.726]    [Pg.37]    [Pg.262]    [Pg.426]    [Pg.624]    [Pg.12]    [Pg.175]    [Pg.416]    [Pg.105]    [Pg.143]    [Pg.33]    [Pg.60]    [Pg.139]    [Pg.1005]    [Pg.37]    [Pg.335]    [Pg.78]    [Pg.460]    [Pg.592]    [Pg.90]    [Pg.77]    [Pg.80]    [Pg.33]    [Pg.60]    [Pg.599]    [Pg.240]   
See also in sourсe #XX -- [ Pg.20 , Pg.32 ]




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Compound preparation

Compounding preparations

Heterocycles containing

Heterocyclic compounds sulfur

Heterocyclic sulfur

Heterocyclic sulfur-containing compounds

Sulfur heterocycles

Sulfur preparation

Sulfur-containing

Sulfur-containing compounds

Sulfur-containing heterocycles

Sulfurated heterocycle

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