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Safety herbal medicines

It is one of the peculiarities of herbal drugs that their indications have for the most part been determijied empirically. The reason is easily understood most herbal drugs have been used for a very long time to alleviate or cure illnesses and more especially disorders. Their introduction in therapeutics happened at a time when pharmacodynamics and pharmacokinetics were unknown concepts, when there was no Medicines Act to require proof of the quality, efficacy, and innocuity of herbal medicines. Today, when introducing a new medicine, extensive investigations are required in the interest of safety. To many the requirement of the proof of activity of such a drug as chamomile appears to be superfluous, but nevertheless, as a representative of a scientifically oriented pharma-... [Pg.19]

Chan TYK. Monitoring the safety of herbal medicines. Drug Safety 17(4) 209-215, 1997. [Pg.744]

Barnes J. (2003) Pharmacovigilance in herbal medicines. A UK perspective. Drug Safety 26 829-851. [Pg.119]

Calixto JB. Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytother-apeutic agents). Braz J Med Biol Res 2000 33 179-89. [Pg.35]

Drew, A.K. and Myers, S.P. (1997) Safety issues in herbal medicine implications for the health professions. Med J Aust 166 538-541. [Pg.374]

Boullata JI, Nace AM. Safety issues with herbal medicine. Pharmacotherapy 2000 20(3) 257-269. [Pg.22]

Farnsworth NR. Relative safety of herbal medicines. HerbalGram 1993 29 36A-36H. [Pg.201]

Anon. Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines. Manila, Philippines World Health Organization, Regional Office for the Western Pacific, 1993. [Pg.203]

However, the information derived from a detailed pharmacokinetic study will help to anticipate potential botanical product-drug interactions, to optimize the bioavailability, the quality, and hence the efficacy of herbal medicines, to support evidence for the synergistic nature of herbal medicines, and to better appreciate the safety and toxicity of the plant. Because pharmacokinetic studies with herbal medicines are often complicated by their chemical complexity and by the fact that the active compounds are often unknown, it could be one future issue to assess bioavailability by measuring surrogate parameters in plasma or tissue instead of directly assaying putative active compounds in the blood. In summary, to use HMPs in an evidence-based approach and to achieve the status rational phytomedicine, more experimental studies are needed to characterize the bioavailability and pharmacokinetics of botanical products. [Pg.235]

As noted above, all available information on the historical use of botanical preparations will be accepted for safety consideration. But for FDA clinical reviewers, such experiences are often poorly documented and difficult to interpret or correlate with the paradigm of conventional (Western) medicine. In the alternative medical system, almost all the diagnoses to be treated with herbal medicine are defined in imprecise and foreign terms. Typically, one herbal medicine is indicated for numerous seemingly unrelated conditions, most of which are symptomatic relief without clear mechanisms. Furthermore, many botanicals are combinations of multiple herbs, but few references are available for the rationale of combining so many ingredients. [Pg.325]

Bent S Herbal medicine in the United States Review of efficacy, safety, and regulation Grand rounds at University of California, San Francisco Medical Center. J Gen Intern Med 2008 23 854. [PMID 18415652]... [Pg.1366]

In order for Chinese herbal medicine to be accepted as reliable alternative medicine, the safety of medicinal herbs and their efficacy for the treatment of specific diseases must be demonstrated.368-385 397 400 A first step is establishing reliable sources... [Pg.15]

Huntley AL, Thompson Coon J, Ernst E. The safety of herbal medicinal products derived from Echinacea species a systematic review. Drug Saf. 2005 28 387-400. [Pg.617]

Herbal medicines are becoming more and more popular, and indeed some herbal products may be considered to benefit people with liver disease, e.g. Silybum marianum (milk thistle), Picrorhiza kurroa, Phyllanthus, etc. Herbal hepatotoxicity is increasingly being recognised, for example, with kava kava, black cohosh, and many traditional Chinese remedies. The range of liver injury includes minor transaminase elevations, acute and chronic hepatitis, steatosis, cholestasis, zonal or diffuse hepatic necrosis, veno-occlusive disease and acute liver failure. In addition to the potential for hepatotoxicity, herb-drug interactions may affect the safety and efficacy of concurrent medical therapy [15]. [Pg.142]

Pharaohs regarded food to be the bearer of both divinity and vital strength. The current interest in the positive health effects of functional foods, nutraceuticals and herbal medicines seems to be a return to the philosophy of ancient Egypt. The public seems to have an impetuous optimistic view about these natural products and so a realistic risk-benefit analysis for these products is not requested by the consumer. As a result these products are consumed without any toxicological hesitation, and concerns on the safety of these products are scarce. [Pg.68]

Herbal products are considered a type of alternative medicine (e.g., herbal medicines, Chinese herbs, homeopathy, acupuncture, biofeedback, color therapy, music therapy, hypnotherapy, aromatherapy. Ayurvedic medicine, massage, therapeutic touch, Bach flower remedies, chiropractic, reflexology, naturopathy, and more). According to the Office of Alternative Medicine of the National Institutes of Health (NIH), characteristics of alternatives medicine include treatments that lack sufficient documentation in the United States for safety and effectiveness against specific disease and... [Pg.2902]

A major contention of the herbal medicine advocacy is the notion that because these entities are natural products, they are somehow safer and better for human consumption. However, the vast majority of alternative medicine products are essentially unregulated and not yet required to demonstrate efficacy, safety, or quality before becoming commercially available. Currently, in the United States, there exists continued debate on what role the FDA should have in regulating and approving alternative medicines. ... [Pg.2903]

In 2002 the Medicines Safety Authority of the Ministry of Health in New Zealand (Medsafe) ordered the withdrawal of several traditional Chinese medicines sold as herbal remedies (4). The products included Guan Xin Su He capsules. Long Dan Xie Gan Wan Pills, and Zhiyuan Xinqinkeli sachets. [Pg.337]

The author of a review of the safety of homeopathic products concluded that they are usually safe, but that continued vigilance is in order, not least because of the currently high popularity of homeopathy (138). In response, it was pointed out that under-reporting is high, that homeopathic products are often mistaken for herbal medicines, and that the main risks of homeopathy relate to the prescriber rather than the medicine (139). [Pg.893]

In a 5-year toxicological study of traditional remedies and food supplements carried out by the Medical Toxicology Unit at Guy s and St. Thomas Hospital, London, 1297 symptomatic enquiries by medical professionals were evaluated (28). Of these, an association was considered to have been confirmed, probable, or possible in 12, 35, and 738 cases respectively. Ten of the confirmed cases were related to Chinese or Indian herbal remedies. As a result of these findings, in October 1996 the UK Committee on Safety of Medicines extended its yellow card scheme for adverse drug reaction reporting to include unhcensed herbal remedies, which are marketed mostly as food supplements in the UK (the scheme had always apphed to hcensed herbal medicines) (29,30). This was an important milestone in herbal pharmacovigilance. [Pg.1610]

Tomassoni AJ, Simone K. Herbal medicines for children an illusion of safety Curr Opin Pediatr 2001 13(2) 162-9. [Pg.1622]


See other pages where Safety herbal medicines is mentioned: [Pg.762]    [Pg.418]    [Pg.96]    [Pg.10]    [Pg.22]    [Pg.66]    [Pg.485]    [Pg.491]    [Pg.492]    [Pg.493]    [Pg.30]    [Pg.69]    [Pg.118]    [Pg.15]    [Pg.38]    [Pg.73]    [Pg.345]    [Pg.83]    [Pg.80]    [Pg.2902]    [Pg.2903]    [Pg.2912]    [Pg.1609]    [Pg.1610]    [Pg.1610]   
See also in sourсe #XX -- [ Pg.2 ]




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