Hepatosplenic candidiasis

Some forms of invasive candidiasis are dominated by deep organ infection and may never be detected by blood cultures. Chronic disseminated candidiasis or hepatosplenic candidiasis is a unique form of candidemia seen after recovery from neutropenia. Candidemia during the period of neutropenia may be initially localized to the portal circulation with dissemination to contiguous organs. After recovery of neutrophils, an inflammatory response is seen against areas of focal infection in the liver and spleen. This inflammatory response produces abdominal pain that is associated with... 

Lipid formulation of amphotericin B IV 3-5 m kg/day Chronic disseminated candidiasis Treatment duration Until calcification or resolution of lesions (hepatosplenic candidiasis) stable patients Fluconazole IV/po 6 mg/kg/day... 

Abelcet) at 5 mg/kg/day and 5 children with hepatosplenic candidiasis were effectively treated with 2.5 mg/kg/day. Safety and efficacy in patients younger than 1 month of age have not been established. 

Eiff, von, M., Essink, M., Roos, N., Hiddemann, W., Buchner, T., van de Loo, J. Hepatosplenic candidiasis, a late manifestation of Candida septicaemia in neutropenic patients with haematologic malignancies. Blut 1990 60 242-248... 

Pastakia, B., Shawker, T.H., Thaler, M., O Leary, T., Pizzo, P.A. Hepatosplenic Candidiasis wheels within wheels. Radiology 1988 166 417-421... 

Lopez-Berestein G, Bodey GP, Frankel LS, Mehta K.Treatment of hepatosplenic candidiasis with iiposomai-amphotericin B. JCiin Oncoi 1987 5 310-7. 

Hepatosplenic candidiasis often is manifested only as fever while the patient remains neutropenic (<1000 WBCs/mm ). 

In patients with hepatosplenic candidiasis, as the WBC count increases to more than 1000 ceUs/mm, imaging smdies can detect the presence of abscess or microabscesses in the liver and spleen, often found with acute suppurative and granulomatous reactions. 

Walsh TJ, Whitcomb PO, Revankar SG, Pizzo PA. Successful treatment of hepatosplenic candidiasis through repeated cycles of chemotherapy and neutropenia. Cancer 1995 76 2357-2362. 

Hepatosplenic candidiasis—Clinical presentation often manifested only as fever while a patient remains neutropenic (<1000 WBC/ mm ). When the WBC count increases to >1000 cells/mm, imaging studies can detect the presence of abscess or microabscesses in the liver and spleen, often found with acute suppurative and granulomatous reactions. Infection may persist for months and ultimately cause the patient s death despite aggressive systemic therapy with antifungal agents. Also known as chronic systemic candidiasis. 

Shirkhoda, A. CT findings in hepatosplenic and renal candidiasis. J. Comput. Assist. Tomogr. 1987 11 795-798... 

Chronic Disseminated Candidiasis (hepatosplenic Treatment duration Until calcification or resolution of lesions... 

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