Candidiasis chronic disseminated

Some forms of invasive candidiasis are dominated by deep organ infection and may never be detected by blood cultures. Chronic disseminated candidiasis or hepatosplenic candidiasis is a unique form of candidemia seen after recovery from neutropenia. Candidemia during the period of neutropenia may be initially localized to the portal circulation with dissemination to contiguous organs. After recovery of neutrophils, an inflammatory response is seen against areas of focal infection in the liver and spleen. This inflammatory response produces abdominal pain that is associated with... 

Lipid formulation of amphotericin B IV 3-5 m kg/day Chronic disseminated candidiasis Treatment duration Until calcification or resolution of lesions (hepatosplenic candidiasis) stable patients Fluconazole IV/po 6 mg/kg/day... 

Answer Chronic disseminated candidiasis (he-patosplenic candidiasis) occurs in patients with profound neutropenia. This patient was appropriately treated for possible fungal sepsis when antibacterial therapy failed to resolve fever in the setting of neutropenia. Despite therapy, however, the patient did have disseminated candidiasis, which persisted in a subchnical state during the long period of neutrope-... 

Chronic Disseminated Candidiasis (hepatosplenic Treatment duration Until calcification or resolution of lesions... 

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