Hepatoprotective effects saponins

The crude saponin mixture of Bupleurum fruticosum and the saikogenin F-triglycoside (buddleyasaponin IV) (61) showed a remarkable hepatoprotective effect as compared with silybin against Gal-N cytotoxicity [66]. 

Given their structural relationship to steroids, many saponins are renowned for their anti-inflammatory effects. Among the most potent are saikosaponins from Bupleurum falcatum and boswellic acid from Boswellia serrata. Saikosaponins are also immunomodulatory and hepatoprotective. Some saponins have been found to reduce... 

Some oleanolic acid-type saponins were known to exhibit similar hepatoprotective activity [4, 7, 32, 42, 43, 44-46]. We also reported the hepatoprotective activity of Palustroside in which has a glucosyl carboxy group at C-28 [47]. As a part of our continuing study, we examined the preventive effects of five oleanolic acid-type glucuronides (90-95), Fig. (8), isolated from Dumasia tnmcata (Table 3) [48]. 

Documented effects In experiment on animals (mice and rats), the preparation Dipsacozide (total plant saponins) was nontoxic and caused short-term decrease in arterial pressure. It noticeably raised the animals tolerance to hypoxia, as found in foothill and high mountain conditions. In lipid metabolism Dipsacozide caused results similar to the known preparation Polysponin, and it also had hepatoprotective abilities (Alimbaeva et al. 1986). 

---