Heparitin sulfate

There are other glycosaminoglycans. Hyaluronic acid [9004-61-9] occurs both free and in noncovalent association with proteoglycan molecules. Heparin [9005-49-6] and heparan sulfate [39403-40-2] also known as heparitin sulfate [9050-30-0] occur in mast cells and in the aorta, Hver, and lungs. 

Heparitin sulfate, 4 706 Hepatitis A vaccine, 25 492-493 Hepatitis B vaccine, 25 491 from yeast, 26 487 Hepatitis B virus (HBV), 3 135 antiviral therapy, 3 154-159 infection process, 3 153-154 Hepatitis B virus detection, method for, 14 153-154... 

Chondroitin sulfate, heparin, and heparitin sulfate chains are linked to the polypeptide backbone by the following linear sequence of sugars ... 

Several studies have shown that hyaluronidase is iidiibited by ft1, Fe Cu +, Ag+, Hg2+, Zn2+, Cd2+, and Pb2+ salts [26,51,58,77,78]. Substrate analogs like chondroitin sulfate tit desulfeted chondroitin sulfate B, dermatan sulfate, keratan sulfate, heparitin sulfate, and heparin were shown to be competitive inhibitors of hyaluronidase [14,54]. 

Heparitin sulfate is composed of D-glucuronic acid, n-glucosamine, acetyl, and sulfate residues in approximately equimolar ratio (J12). The structure of heparitin sulfate still awaits final elucidation, but it may be distinguished from other sulfated mucopolysaccharides by means of its high positive rotation, electrophoretic behavior, and resistance to testicular, bacterial, and leech hyaluronidases. Final identification, however, usually requires its isolation and analysis. 

C6. Cifonelli, J. A., and Dorfman, A., Structural studies on herapin and heparitin sulfate. Biochem. Biophys. Res. Commun. 4, 328-331 (1961). 

L5. Linker, A., and Sampson, P., The enzymic degradation of heparitin sulfate. Biochim. Biophys. Acta 43, 366-368 (1960). 

The proof of this sequence, and of the nature of the carbohydrate-peptide bond, was based on enzymic erosion to a glycopeptide fragment that was then studied by adaptations of classical methods. A similar linkage-region probably occurs in heparin,86 heparitin sulfate,87 dermatan sulfate88 and chondroitin 6-sulfate.88a It is possible that the polypeptide core itself is branched.89... 

Heparan sulfate Heparin monosulfate Acetylheparan sulfate Heparitin Heparan Heparin sulfate Heparin monosulfuric acid Heparitin sulfate... 

Heparitin sulfate, heparan sulfate a monosulfate ester of an acetylated (IV-acetyl) heparin. As isolated from animal tissues (liver), H. s. is probably a mixture of mucopolysaccharides with varying degrees of sulfa-tation or amino group acetylation. 

I Hurler s disease Autosomal recessive Dwarfism, gargoyle facies, mental retardation, early death Chondroitin sulfate B and heparitin sulfate... 

III Polydystrophic oligophrenia, Sanfilippo s disease Autosomal recessive Minor somatic changes, severe mental retardation Heparitin sulfate... 

Laboratory findings are characterized by increased urinary excretion of mucopolysaccharides (Dorfman and Lorincz 1957), with values of 60 mg per liter and more as compared to normal values of 5—10 mg per liter. The urinary mucopolysaccharides in HD consist of chondroitinsulfate B and heparitin sulfate (Dorfman and Lorincz 1957, Meyer et al. 1958) with a 2 1 ratio. The occurrence of both mucopolysaccharides is used for distinction of HD from other mucopolysaccharidoses or other disorders associated with increased mucopolysaccharide excretion, such as the Marfan syndrome (Berenson and Dalferes 1965). The finding of a smaller proportion of heparitinsulfate in HD as compared to the sex-linked mucopolysaccharidosis II (see table 8) (Terry and Linker 1964) is not obligatory. Increased arylsulfatase B activity was found in the urine of patients with HD by Austin et al. (1964). 

As already mentioned in the preceding section, there is a marked similarity between the chemical constitutions and chemical properties of heparan sulfate and of heparin. Thus, it has been proposed to place in the same class of compounds the dextrorotatory sulfated pol3rsaccharides composed of D-glucosamine and D-glucuronic acid residues", such as the heparin monosulfate , the heparitin sulfates" with various degrees of sulfation, and the heparins with various degrees of sulfation . 

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