Heparin-binding EGF-like growth factor

Proteolytic processing of membrane-anchored proteins is an important event. TNE-a, TGF-(x, EGF, heparin-binding EGF-like growth factor (HB-EGF), the Kit ligand, and other growth factors must all be processed to become functional. Processing has other... 

S- Higashiyama, K Lau, G. E. Besner, J. A. Abraham, and M. Klagsbrun. Structure of heparin-binding EGF-like growth factor. Mult le forms, primaTy structure, and glycosylation of the mature protein. 3 Bid Ghent, 267 (9), 6205-6212, 1992. 

Heparin-binding EGF-like growth factor (HBEGF) Diptheria toxin TM... 

Nanba D, Higashiyama S. Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor. Cytokine Growth Factor Reviews. 2004 15 13-19. 

Naglich JG, Metherall JE, Russell DW, Eidels L (1992) Expression cloning of a diphtheria toxin receptor Identity with a heparin-binding EGF-like growth factor precursor. Cell 69 1051-1061. 

Paria BC, Elenius K, Klagsbrun M, Dey SK. Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbBl a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation. Development 1999 126 1997-2005. 

Raab G, Kover K, Paria BC, Dey SK, Ezzell RM, Klagsbrun M. Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor. Development 1996 122 637-645. 

Armant DR, Kilburn BA, Petkova A, Edwin SS, Duniec-Dmuchowski ZM, Edwards HJ, Romero R, Leach RE. 2006. Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor. Development 133(4) 751-759. 

Tse AC, Ge W. 2009. Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands. Comp Biochem Physiol A Mol Integr Physiol 153(1) 13-17. 

Moreover, heparin-functionalized thermoresponsive cell culture surfaces have an affinity interaction with heparin-binding EGF-like growth factor (HB-EGF), which is a potent mitogen for hepatocytes [41]. An HB-EGF-bound heparin-functionalized thermoresponsive surface was utilized for creating hepatocyte sheets with maintaining hepatic functions during cultivation [42]. The addition of HB-EGF in the cell culture media was es-sentialfor the survival of hepatocytes. When the medium contained less than 10 ng/cm of soluble HB-EGF, the hepatocytes were not able to adhere and form their cell sheets. Hepatocytes adhered well and formed their sheets on the HB-EGF-bound heparin-functionalized... 

Heparin-binding EGF-like growth factor (HB-EGF), produced locally by vascular macrophages and SMCs, has been suggested to induce the migration and proliferation of VSMCs. HB-EGF mRNA is abundantly expressed in human adipose tissue. Also, plasma HB-EGF levels increase in parallel with fat accumulation in humans, and the subjects with CAD have higher plasma HB-EGF levels, associated with fat accumulation (295). 

The role of Apo B containing lipoproteins other than LDL has been reviewed in ref. 411. pVLDL enhances iNOS expression and nitrite accumulation in IL-1 -stimulated VSMC (412). xi rat aortic SMC, remnant lipoproteins transactivate EOF receptor via PKC and the shedding of membrane-bound soluble heparin-binding EGF-like growth factor from SMCs, resulting in SMC proliferation (413). 

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