Hemorrhage parenchymal

Evidence of intracranial hemorrhage, subarachnoid hemorrhage, or a large area of cerebral edema, parenchymal hypodensities, or sulcal effacement on pretreatment CT scan... 

Another prominent site of deposition of (5-amyloid fibrils with age and in AD is within the cerebrovasculature in areas of the brain prone to parenchymal amyloid deposition [137-139]. The peptide deposits along the surfaces of the smooth muscle cells of the vascular wall, resulting in the death of those cells and their replacement by amyloid fibrils, weakening the vascular wall. Endothelial cells are also affected [140]. The Dutch mutation in the APP precursor protein Q22E, within the (5-peptide sequence, produces a particularly fibrillogenic and toxic (to smooth muscle cells) peptide associated with primarily vascular deposition of mutant peptide and hemorrhagic vessel disease [137]. Thus, in addition to neuronal cells, the brain vascular smooth muscle cells are a pathologically relevant cell type. While the source of... 

In the previous sections we have, by part, already reviewed delayed effects after cerebral ischemia, such as the risk of hemorrhagic complications that may occur as petechial bleedings or parenchymal hematoma. We have seen that the blood-brain barrier opens to various degrees with a substantial time... 

Neurological involvement in Behcet s disease may be subclassified into two major forms a vascular-inflammatory process with focal or multifocal parenchymal involvement and a cerebral venous sinus thrombosis with intracranial hypertension. The vasculitis and meningitis may affect cerebral arteries, particularly in the posterior circulation, to cause ischemic stroke and possibly intracranial hemorrhage (Farah et al. 1998 Krespi et al 2001 Siva et al. 2004 Borhani Haghighi et al. 2005). 

A 56-year-old man is admitted to the coronary care unit with myocardial infarction. You would like to attempt dissolution of the coronary occlusion with a thrombolytic agent. Recent medical history includes a streptococcal throat infection (1 month previously) and hemorrhage from a tooth socket following a difficult extraction (6 months previously). His problem list includes renal parenchymal disease. He has been taking aspirin, one 325-mg tablet daily, for the last 6 years. Which of the following is most correct ... 

Atlas SW, Thulborn KR (1998) MR detection of hyperacute parenchymal hemorrhage of the brain. Am J Neuroradiol 19 1471-1507. 

BBB disruption and development of vasogenic edema. Decreased perfnsion pressnre and decreased cerebral blood flow lead to the failnre of the Na /KVATPase pump, which then leads to cytotoxic edema [74]. Parenchymal hndings on MR include cerebral swelling, venons infarctions, and gross or petechial intracranial hemorrhage, often in a nonarterial distribution. 

Hjort, N., et al., MRI detection of early blood-brain barrier disruption parenchymal enhancement predicts focal hemorrhagic transformation after thrombolysis. Stroke, 2008. 39(3) p. 1025-8. 

Parenchymal swelling with sulcal effacement Intraparenchymal edema Intraparenchymal hemorrhage Venous clot... 

PROACTII <6h 4< <30 but not comatose (except for isolated aphasia or hemianopia) No intracranial tumors, hemorrhage, significant mass effect with midline shift, or acute hypodense parenchymal lesion or effacement of cerebral sulci in >1/3 of the middle cerebral artery (MCA) territory UMI grade 1 of either the Ml segment or an M2 division of MCA... 

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