Hemorrhagic transformation

Neumann-Haefelin C, Brinker G, Uhlenkuken U, Pillekamp F, Hossmann KA, Hocehn M. Prediction of hemorrhagic transformation after thrombolytic therapy of clot embolism an MRI investigation in rat brain. Stroke 2002 33 1392-1398. [Pg.37]

Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model Diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab. 2001 21 964-971. [Pg.55]

Del Zoppo GJ, Copeland BR, Anderchek K, Hacke W, Koziol JA. Hemorrhagic transformation following tissue plasminogen activator in experimental cerebral infarction. Stroke. 1990 21 596-601. [Pg.56]

Larrue V, von Kummer R, del Zoppo G, Bluhmki E. Hemorrhagic transformation in acute ischemic stroke. Potential contributing factors in the European Cooperative Acute Stroke Study. Stroke. 1997 28 957-960. [Pg.57]

Fiorelli M, Bastianello S, von Kummer R, del Zoppo GJ, Larrue V, Lesaffre E, Ringleb AP, Lorenzano S, Manelfe C, Bozzao L. Hemorrhagic transformation within 36 hours of a cerebral infarct Relationships with early clinical deterioration and 3-month outcome in the european cooperative acute stroke study i (ECASS i) cohort. Stroke. 1999 30 2280-2284. [Pg.57]

Larrue V, von Kummer RR, Muller A, Bluhmki E. Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator A secondary analysis of the european-australasian acute stroke study (ECASS II). Stroke. 2001 32 438 1. [Pg.57]

The neurointerventionalist should limit the number of microcatheter injections performed during the exam, as there is growing evidence that this may increase the chances of hemorrhagic transformation of the infarcted tissue. Direct injection of contrast into stagnant vessels, which contains injured glial cells and thus breakdown of the blood-brain barrier, allows for contrast extravasation. Contrast is readily visualized on the immediate post-thrombolysis CT as an area of high attenuation in the parenchyma. In some instances, MRI with susceptibility-weighted sequences may be useful to differentiate contrast extravasation from Such a distinction... [Pg.74]

Sumii T, Lo EH. Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embohc focal ischemia in rats. Stroke 2002 33 831-836. [Pg.119]

At total of 75% of cardiac emboli reach the brain. Non-valvular atrial fibrillation with thrombus formation within the left atrial appendix or the left atrium is the most common reason for cardiac emboli (Ferro 2003). Cardio-embolic infarcts within the MCA territory carry a high risk for hemorrhagic transformation after reperfusion. Hemor-... [Pg.10]

Mokri B, Silbert PL, Schievink WI et al (1996) Cranial nerve palsy in spontaneous dissection of the extracranial internal carotid artery. Neurology 46 356-359 Molina CA, Montaner J, Abilleira S et al (2001) Timing of Spontaneous Recanalization and Risk of Hemorrhagic Transformation in Acute Cardioembolic Stroke. Stroke 32 1079-1084 Molina CA, Alvarez-Sabin J, Montaner J et al (2002) Thrombolysis-related hemorrhagic infarction a marker of early reperfusion, reduced infarct size, and improved outcome in patients with proximal middle cerebral artery occlusion. Stroke 33 1551-1556... [Pg.16]

Selim M, Fink JN, Kumar S, Caplan LR, Horkan C, Chen Y, Linfante I, Schlaug G (2002) Predictors of hemorrhagic transformation after intravenous recombinant tissue plasminogen activator prognostic value of the initial apparent diffusion coefficient and diffusion-weighted lesion volume. Stroke 33 2047-2052... [Pg.40]

Knight RA, Barker PB, Fagan SC, Li Y, Jacobs MA, Welch KM (1998) Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats. Stroke 29 144-151... [Pg.70]

Vo KD, Santiago F, Lin W, Hsu CY, Lee Y, Lee JM (2003) MR imaging enhancement patterns as predictors of hemorrhagic transformation in acute ischemic stroke. AJNR Am J Neuroradiol 24 674-679... [Pg.148]

Simultaneous or sequential strokes in different arterial territories, multi-level posterior circulation infarcts, simultaneous infarcts in the three subterritories (superficial anterior, superficial posterior and deep) of the MCA, and hemorrhagic transformation of an ischemic infarct also point to a cardiac origin of the stroke (Arquizan et al. 1997 Ay et al. 1999 Ferro 2003a,b). Occlusion of the carotid artery by a mobile thrombus, early recanalization of an occluded vessel and the identification of microembolism in both MCAs are all highly indicative of a cardiac source of emboli. [Pg.220]

Alexandrov AV, Black SE, Ehrlich LE et al (1997) Predictors of hemorrhagic transformation occurring spontaneously and on anticoagulants in patients with acute ischemic stroke. Stroke 28 1198-1202... [Pg.221]

Studer A, Georgiadis D, Baumgartner RW (2003) Ischemic infarct involving all arterial territories of the thalamus. Acta Neurol Scand 107 423-425 Timsit SG, Sacco RL, Mohr JP et al (1992) Early clinical differentiation of cerebral infarction from severe atherosclerotic stenosis and cardioembolism. Stroke 23 486-491 Tong DC, Adami A, Moseley ME et al (2000) Relationship between apparent diffusion coefficient and subsequent hemorrhagic transformation following acute ischemic stroke. Stroke 31 2378-2384... [Pg.224]

Shimizu T., Naritomi H., OeH., et al. (1996) Mild hypothermia prevents the development of cerebral edema and hemorrhagic transformation in acute embolic stroke. Cerebrovasc. Dis. (Suppl 2), 32-178. [Pg.117]

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