Blood substitutes hemoglobin based

Blood Substitutes Hemoglobin-Based Oxygen Carriers... 

AH of the reactions considered to be useful in the production of hemoglobin-based blood substitutes use chemical modification at one or more of the sites discussed above. Table 2 Hsts the different types of hemoglobin modifications with examples of the most common reactions for each. Differences in the reactions are determined by the dimensions and reactivity of the cross-linking reagents. Because the function of hemoglobin in binding and releasing... 

Chang TM. Modified hemoglobin-based blood substitutes crosslinked, recombinant and encapsulated hemoglobin. Vox Sang 74(suppl 2) 233, 1998. 

The rapid reaction of nitrogen monoxide with oxyhemoglobin (oxyHb) is of particular interest, because it significantly reduces the half-life of NO in vivo and is the cause of increased blood pressure observed when extracellular hemoglobin-based blood substitutes are administered [16]. 

Alayash, A.I. Hemoglobin-based blood substitutes oxygen carriers, pressor agents, or oxidants Nature Biotech. 1999,17, 545-549. 

Komiyama N, Tame J, Nagai K. A hemoglobin-based blood substitute transplanting a novel allosteric effect of crocodile hemoglobin. Biol Chem 1996 377 543-548. 

Olson JS, Foley EW, Rogge C, et al. No scavenging and the hypertensive effect of hemoglobin-based blood substitutes. Free Radio Biol Med 2004 36 685-697. 

Chen J, Scerbo M, Kramer G. Review of blood substitutes examining the history, clinical trail results and ethics of hemoglobin-based oxygen carriers. Chnics 2009 64 803-13. 

Chang TM. Nanobiotechnology for hemoglobin-based blood substitutes. Crit Care Clin 2009 25(2) 373-82. 

Natanson C, Kern SJ, Lurie P, Ranks SM, Wolfe SM. Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death a meta-analysis. JAMA 2008 299(19) 2304-12. 

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