Hematopoietic/nonhematopoietic cells

SCF (recombinant product ancestim) is an early-acting hematopoietic growth factor that stimulates the proliferation of primitive hematopoietic and nonhema-topoietic cells [7]. In vitro, SCF has minimal effect on hematopoietic and nonhematopoietic progenitor cells, but it synergistically increases the activity of other hematopoietic growth factors, such as G-CSF, GM-CSF, and EPO. SCF stimulates the generation of dendritic cells in vitro and mast cells in vivo. 

IL-18 Hematopoietic and nonhematopoietic lineage cells T cells, NK cells Proinflammatory cytokine IFN-y-inducing factor... 

Potential Implications of HSCs. Studies on bone marrow cells differentiating into nonhematopoietic lineages have proposed that the cells are a representa-tive source of cell replacement in the treatment of numerous diseases. To amplify and generalize this issue for clinical translation, we should accumulate the useful processes of regeneration of blood formation by HSCs [36], skin replacement by putative epidermal stem cells [87], and the benefits reported in treating patients with myocardial infarction with bone marrow cells, mobilized peripheral HSCs, or hematopoietic progenitors [88, 89]. 

Iwatani H, Ito T, Imai E, et al. (2004). Hematopoietic and nonhematopoietic potentials of Hoechst(low)/side population cells isolated from adult rat kidney. Kidney Int. 65 1604-1614. 

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