Reports benefits

Ancillary treatments such as humidifiers, vaporizers, and saline nasal sprays or drops are used to moisturize the nasal canal and impair crusting of secretions along with promoting ciliary function. Although many patients report benefit from such therapies, there are no controlled studies that support their use.32,34,36... 

Tiagabine blocks neuronal uptake of GABA and has reported benefits in panic disorder and PTSD (Lydiard 2003). Topiramate has complex actions on GABA and glutamate and was found to be helpful for some symptoms of PTSD (Berlant and van Kammen 2002). Vigabatrin inhibits GABA metabolism and has been shown to block induced panic attacks in healthy volunteers (Zwanzger et al. 2001). 

FDA, An FDA center for drug evaluation and research report, Benefits vs. Risk. How CDER approves new drug 2000. 

Notwithstanding the initial effects of sleep inertia that may accompany long naps, they have been shown to produce beneficial effects after normal nocturnal sleep (26-29), sleep restriction (30), total sleep deprivation (31), as well as during experimental night shifts (32,33) and periods of sustained wakefulness (1). Reported benefits include increased post-nap sleep latency (30,31,33), improved... 

Research has shown that deficits resulting from nocturnal sleep restriction can be ameliorated by brief naps of mean durations as short as 19.8 (5), 10.8 (36), 10.2 (37), and 10 min (20,38,39). Brief naps of mean durations of 7.3 min (40) and 20 min (41,42) after normal nocturnal sleep, and brief workplace naps during the night shift (35,43) have also been shown to be beneficial. Reported benefits of brief naps include increased sleep latency (20,38,39), EEG indicators of increased alertness (5,36,37,41,42,44), improved subjective alertness (5,20,39- 41,44), reduced fatigue (20,39), and improved performance accuracy (5,40,41,44,45), performance productivity (20,38,39,45), response speed (20,35,43,45) and simulated driving performance (36). 

Due to wide variations in the manner in which corporations report benefits to the U.S. Government s regulatory bodies, not all plans will have been uncovered or correctly evaluated during our effort to research this data. Also, the availability to employees of such plans will vary according to the qualifications that employees must meet to become eligible. For example, some benefit plans may be available only to salaried workers—others only to employees who work more than 1,000 hours yearly. Benefits that are available to employees of the main or parent company may not be available to employees of the subsidiaries. In addition, employers frequently alter the nature and terms of plans offered. 

Burr and Burr reported in 1929 a new deficiency disease produced by the rigid exclusion of fat from the diet. 1 Rodents fed a fat-free diet showed reduced growth and reproductive failure, accompanied by two prominent changes in the skin, that is, increased scaliness and impaired barrier function.1,2 Reversal of the features of deficiency by administration of linoleic acid (LA), led to the concept of essential fatty acids (EFA) that cannot be synthesized by the higher animals.2 Similarities between the clinical features of EFA deficiency and atopic dermatitis led Hansen in 1937 to discover low blood levels of unsaturated fat in atopic children,3 and he later reported that EFA-deficient infants developed an eczematous rash, which responded to LA supplements.4 Several studies had previously examined a range of dietary oil supplements in atopic dermatitis,5-8 with generally reported benefit. 

In 1908 Elie Metchnikoff was awarded the Nobel Prize for his work with the lactic acid bacteria (LAB). He reported that populations that ingested soured milk such as the Bulgarians were known for their longevity. He studied intestinal microflora and reported that LAB were beneficial to human health, making him the first scientist to report benefits of these organisms. Since then, numerous scientists have studied not only the health benefits associated with the LAB, but also the concept of microbial antagonism of the LAB toward food-borne pathogens. 

Among five prospective, placebo-controlled trials, three reported benefit with flumazenil, whereas two found no difference when compared to placebo. With dosages of 0.2 to 15 mg IV, response rates were variable, ranging from 17% to 78% improvements, however, were often transient. Flumazenil, which is only available in an intravenous dosage form, may be considered for short-term therapy in refractory patients, but cannot be recommended for routine clinical use. 

Tamoxifen was shown to have a response and survival benefit in a randomized trial when combined with dacarbazine in patients with metastatic melanoma this benefit was most pronounced in women. Well designed prospective randomized studies demonstrate that tamoxifen does not significantly enhance the antitumor effect of dacarbazine alone or of the combination of dacarbazine with cisplatin and carmustine. As discussed previously, subsequent trials have not been able to confirm the initial reported benefit of the antiestrogen when combined with chemotherapy, and tamoxifen is no longer routinely included in chemotherapy regimens. 

Sandler, 2005) and illustrates once again the necessity of placebo-controlled study designs for evaluating ASD pharmacotherapies. Notably, the results from this study are at variance with previous open-label studies that reported benefits for citalo-pram in ASD (reviewed by Posey et ah, 2006). In addition, adverse events were significantly more frequent overall with citalopram than with placebo, with significant increases in energy level, impulsiveness, impaired attention and concentration, hyperactivity, stereotypy, and insomnia. 

It will be interesting to observe how these reported benefits from the exploitation of these switch pocket residues may translate into advantages in the clinic. 

Do not overtreat with excessive sedation. One study reported benefit with a continuous infusion of midazolam in patients with severe Centruroides sting. 

These many new forms have afforded researchers with vehicles to have improved chemistries and to offer multiple benefits. Additionally, for added convenience, many of the product types can be purchased in unit dose form. Unitized doses of dishwashing detergents are more attractive because they alleviate the need for precise dosing and avoid wasteful overdosing. Packaging materials have been developed such that one dose could have several layers or compartments that break down and dissolve over the wash or with specific triggers. " Sharma et al., for example, discuss a multicomponent pouch that can deliver a powder form on one side and liquid/gel form on the other side. Some of these newer product forms with their reported benefits can be seen in Figure 3.8. 

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