Helicobacter vaccines

McAtee CP et al. Characterization of a Helicobacter pylori vaccine candidate by proteome techniques. J Chromatogr B Biomed Sci Appl 1998 714 325-333. 

Nilsson CL et al. Identification of protein vaccine candidates from Helicobacter pylori using a preparative two-dimensional electrophoretic procedure and mass spectrometry. Anal Chem 2000 72 2148-2153. 

Secondly, getting the genomes for important human pathogens has been driven by the desire to identify every possible molecular target for the development of drugs or vaccines for the associated diseases. Among these efforts are several viral genomes and those of Helicobacter, Treponema, Haemophilus, Borrelia, and Mycoplasma, all mentioned earlier. 

J.L. Telford, and P. Ghiora, Prospects for development of a vaccine against Helicobacter pylori. Drugs 52 799-804, 1996. 

The maximal intestinal immunization can be achieved by intra-Peyer s patch immunization, and thus this method can be used to screen oral vaccine candidate antigens without the added complication of simultaneously testing oral-delivery systems. Immunization of subjects against Helicobacter pylori by intra-Peyer s patch resulted in an 84-91% reduction in H. pylori infection compared with unimmrmized controls. The therapeutic efficacy of the recombinant H. pylori urease vaccine in mice was shown to be comparable with that achieved with the combined anti-biotic/antacid treatment in humans. The oral vaccination is preferred to conventional treatment of ulcers because it is a very simple and quick procedure compared with long-term conventional treatment. In addition, vaccines use the defense mechanisms of the body to establish long-lasting immunity. ... 

Oligosaccharide mimics of the O-antigens of many bacterial pathogens, including E. coli [236], Helicobacter pylori [237], Shigella flexneri [238,239] and Vibrio cholerae [240,241] have been synthesized and evaluated for use in antibacterial vaccines (O Fig. 16). 

Edible vaccines for Helicobacter pylori and rotaviruses Deprohealth project, http // www.flair-flow.com/consumer-docs / ffe63503.html 2004. 

McAtee, C.P., Fry, K.E., and Berg, D.E. 1998a, Identification of potential diagnostic and vaccine candidates of Helicobacter pylori by "proteome" technologies. Helicobacter 3 163-169. 

DiPetrillo, M. D., Tibbetts, T., Kleanthous, H., Killeen, K. P. and Hohmann, E. L. 1999, Safety and immunogenicity of phoP/phoQ-deleted Salmonella typhi expressing Helicobacter pylori urease in adult volunteers. Vaccine, 18 449-459 Donahue, J. P., Israel, D. A., Torres, V. J., Necheva, A. S. and Miller, G. G. 2002, Inactivation of a Helicobacter pylori DNA methyltransferase alters dnaK operon expression following host-cell adherence. FEMS Microbiol.Lett., 208 295-301 Donati, M., Moreno, S., Stomi, E., Tucci, A., Poll, L., Mazzoni, C., Varoli, O., Sambri,... 

Keenan, J., Oliaro, J., Domigan, N., Potter, H., Aitken, G., Allardyce, R. and Roake, J. 2000, Immune response to an 18-kilodalton outer membrane antigen identifies lipoprotein 20 as a Helicobacter pylori vaccine candidate. Infect.Immun., 68 3337-3343... 

Kleanthous, H., Lee, C. K. and Monath, T. P. 1998, Vaccine development against infection with Helicobacter pylori. Br.MedBull., 54 229-241 Kotloff, K. L., Sztein, M. B., Wasserman, S. S., Losonsky, G. A., DiLorenzo, S. C. and Walker, R. I. 2001, Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection. Infect.Immun., 69 3581-3590 Kreiss, C., Buclin, T., Cosma, M., Corthesy-Theulaz, I. and Michetti, P. 1996, Safety of oral immunisation with recombinant urease in patients with Helicobacter pylori infection. Lancet, 347 1630-1631... 

Nilsson, C. L., Larsson, T., Gustafsson, E., Karlsson, K. A. and Davidsson, P. Identification of protein vaccine candidates from Helicobacter pylori using a preparative two-dimensional electrophoretic procedure and mass spectrometry. Anal.Chem.2000.May.l. 72.(9.) 2148.-53., 72 2148-2153... 

Zevering, Y., Jacob, L. and Meyer, T. F. 1999, NaturaUy acquired human immune responses against Helicobacter pylori and implications for vaccine development. Gut, 45 465-474... 

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